Top

Published in:

Open Access 01-09-2009 | Original Article

Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation

Authors: Assia Bassarova, Gunhild Trøen, Alexander Fosså, Ida Munster Ikonomou, Klaus Beiske, Jahn M. Nesland, Jan Delabie

Published in: Journal of Hematopathology | Issue 3/2009

Abstract

Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcription factor that is important for maintaining B cell identity and is frequently mutated in B cell lymphomas of germinal center cell origin, might be a cause for loss of PAX-5 expression and thus B cell phenotype. However, no somatic hypermutation of the PAX-5 gene was detected in the two cases we studied. The molecular basis for transdifferentiation of B cell lymphoma to histiocytic sarcoma remains therefore unresolved.

Jaffe R, Pileri S, Facchetti F, Jones DM, Jaffe ES (2008) Histiocytic and dendritic neoplasms. In: Swerdlow S et al (eds) World Health Organization classification of tumors. Tumours of haematopoietic and lymphoid tissues, 4th edn. IARC, Lyon, p 354

Pileri SA, Grogan TM, Harris NL et al (2002) Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 41:1–29CrossRefPubMed

Nichols CR, Roth BJ, Heerema N et al (1990) Hematologic neoplasia associated with primary mediastinal germ-cell tumors. N Engl J Med 322:1425–1429PubMedCrossRef

Baer MR, Krantz SB, Cousar JB et al (1986) Malignant histiocytoses developing in patients with B-cell lymphomas. Report of two cases. Cancer 57:2175–2184CrossRefPubMed

Wetzler M, Kurzrock R, Goodacre AM et al (1995) Transformation of chronic lymphocytic leukemia to lymphoma of true histiocytic type. Cancer 76:609–617CrossRefPubMed

Vasef MA, Zaatari GS, Chan WC et al (1995) Dendritic cell tumors associated with low-grade B-cell malignancies. Report of three cases. Am J Clin Pathol 104:696–701PubMed

Feldman AL, Arber DA, Pittaluga S et al (2008) Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood 111:5433–5439CrossRefPubMed

Pasqualucci L, Neumeister P, Goossens T et al (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412:341–346CrossRefPubMed

Nutt SL, Heavey B, Rolink AG, Busslinger M (1999) Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:556–562CrossRefPubMed

10.

van Dongen JJ, Langerak AW, Brüggemann M et al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257–2317CrossRefPubMed

11.

Mullighan GC, Goorha S, Radtke I et al (2007) Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446:758–764CrossRefPubMed

12.

Halldorsdottir AM, Fruhwirth M, Deutsch A et al (2008) Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma. Leuk Res 32:1015–1021CrossRefPubMed

Title: Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
Authors: Assia Bassarova
Gunhild Trøen
Alexander Fosså
Ida Munster Ikonomou
Klaus Beiske
Jahn M. Nesland
Jan Delabie
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Journal of Hematopathology / Issue 3/2009
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-009-0031-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2009

UK-based real-time lymphoproliferative disorder diagnostic service to improve the management of patients in Ghana

New developments in the pathology of malignant lymphoma: a review of the literature published from January to August 2009

Journal of Hematopathology listed in PubMed!

Recent advances in bone marrow biopsy pathology

Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm

Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factors