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Cancer Microenvironment
Published in: Cancer Microenvironment 1/2019

01-04-2019 | Metastasis | Editorial

Editorial Comment: Deciphering the “Metastasome” Leads to Novel Hypotheses on Understanding the Evolution of Metastasis and Implicates Consequences for Metastasis Therapy and Prevention

Author: Heike Allgayer

Published in: Cancer Microenvironment | Issue 1/2019

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Excerpt

The utmost challenge in cancer therapy undoubtedly still is the successful combat or even prevention of metastasis, which still can arise even years after successful primary tumor therapy or already during an ongoing, even personalized therapy of a cancer patient. Still, metastases are by far the most frequent causes for cancer deaths and we still are facing a situation of rather fragmented research at metastasis, a still incomplete understanding of metastasis evolution, and clinical protocols which often are not, or cannot, be specifically designed to target the metastatically relevant tumor cell clones. …
Literature
1.
2.
3.
Ishaque N, Abba ML, Hauser C, Patil N, Paramasivam N, Huebschmann D, Leupold JH, Balasubramanian GP, Kleinheinz K, Toprak UH, Hutter B, Benner A, Shavinskaya A, Zhou C, Gu Z, Kerssemakers J, Marx A, Moniuszko M, Kozlowski M, Reszec J, Niklinski J, Eils J, Schlesner M, Eils R, Brors B, Allgayer H (2018, Nov 14) Whole genome sequencing reveals novel hypotheses on metastasis evolution and therapy in colorectal cancer. Nat Commun 9(1):4782. https://​doi.​org/​10.​1038/​s41467-018-07041-z CrossRefPubMedPubMedCentral
4.
Vogelstein B, Kinzler KW (1993) The multistep nature of cancer. Trends Genet TIG 9:138–141
Metadata
Title
Editorial Comment: Deciphering the “Metastasome” Leads to Novel Hypotheses on Understanding the Evolution of Metastasis and Implicates Consequences for Metastasis Therapy and Prevention
Author
Heike Allgayer
Publication date
01-04-2019
Publisher
Springer Netherlands
Published in
Cancer Microenvironment / Issue 1/2019
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI
https://doi.org/10.1007/s12307-019-00221-5

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