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01-04-2019 | Lymphoma | Review

The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders

Authors: Lukas Marcelis, Thomas Tousseyn

Published in: Cancer Microenvironment | Issue 1/2019

Abstract

Post-transplant lymphoproliferative disorders (PTLDs) cover a broad spectrum of lymphoproliferative lesions arising after solid organ or allogeneic hematopoietic stem cell transplantation. The composition and function of the tumor microenvironment (TME), consisting of all non-malignant constituents of a tumor, is greatly impacted in PTLD through a complex interplay between 4 factors: 1) the graft organ causes immune stimulation through chronic antigen presentation; 2) the therapy to prevent organ rejection interferes with the immune system; 3) the oncogenic Epstein-Barr virus (EBV), present in 80% of PTLDs, has a causative role in the oncogenic transformation of lymphocytes and influences immune responses; 4) interaction with the donor-derived immune cells accompanying the graft. These factors make PTLDs an interesting model to look at cancer-microenvironment interactions and current findings can be of interest for other malignancies including solid tumors. Here we will review the current knowledge of the TME composition in PTLD with a focus on the different factors involved in PTLD development.

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Title: The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders
Authors: Lukas Marcelis
Thomas Tousseyn
Publication date: 01-04-2019
Publisher: Springer Netherlands
Keywords: Lymphoma
Mononucleosis
Epstein-Barr Virus
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
Mononucleosis
Published in: Cancer Microenvironment / Issue 1/2019
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-018-00219-5

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