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Cancer Microenvironment
Published in: Cancer Microenvironment 2/2012

01-08-2012 | Review Paper

Origin and Functions of Tumor-Associated Myeloid Cells (TAMCs)

Authors: Antonio Sica, Chiara Porta, Sara Morlacchi, Stefania Banfi, Laura Strauss, Monica Rimoldi, Maria Grazia Totaro, Elena Riboldi

Published in: Cancer Microenvironment | Issue 2/2012

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Abstract

The construction of an inflammatory microenvironment provides the fuel for cancer development and progression. Hence, solid tumors promote the expansion and the recruitment of leukocyte populations, among which tumor-associated myeloid cells (TAMCs) represent a paradigm for cancer-promoting inflammation. TAMCs group heterogeneous phagocytic populations stemming from a common myeloid progenitor (CMP), that orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; immunosuppression; cell growth; angiogenesis; matrix deposition and remodelling; construction of a metastatic niche and actual metastasis. Several evidence indicate that TAMCs show plasticity and/or functional heterogeneity, suggesting that tumour-derived factors promote their functional “reprogramming” towards protumoral activities. While recent studies have attempted to address the role of microenvironment signals, the interplay between cancer cells, innate and adaptive immunity is now emerging as a crucial step of the TAMCs reprogramming. Here we discuss the evidence for the differentiation of TAMCs during the course of tumor progression and the molecular mechanisms that regulate such event.
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Metadata
Title
Origin and Functions of Tumor-Associated Myeloid Cells (TAMCs)
Authors
Antonio Sica
Chiara Porta
Sara Morlacchi
Stefania Banfi
Laura Strauss
Monica Rimoldi
Maria Grazia Totaro
Elena Riboldi
Publication date
01-08-2012
Publisher
Springer Netherlands
Published in
Cancer Microenvironment / Issue 2/2012
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI
https://doi.org/10.1007/s12307-011-0091-6

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