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Cancer Microenvironment
Published in: Cancer Microenvironment 1/2012

01-04-2012 | Original Paper

The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis

Authors: Eileen L. Heinrich, Tonya C. Walser, Kostyantyn Krysan, Elvira L. Liclican, Jeanette L. Grant, Nicole L. Rodriguez, Steven M. Dubinett

Published in: Cancer Microenvironment | Issue 1/2012

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Abstract

The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.
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Metadata
Title
The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis
Authors
Eileen L. Heinrich
Tonya C. Walser
Kostyantyn Krysan
Elvira L. Liclican
Jeanette L. Grant
Nicole L. Rodriguez
Steven M. Dubinett
Publication date
01-04-2012
Publisher
Springer Netherlands
Published in
Cancer Microenvironment / Issue 1/2012
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI
https://doi.org/10.1007/s12307-011-0089-0

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