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01-12-2010 | Review Paper

The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade

Authors: Xiao-Feng Le, Omar Merchant, Robert C. Bast Jr., George A. Calin

Published in: Cancer Microenvironment | Issue 1/2010

Abstract

Cancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in the circulation; 5) extravasation into distant organs; and 6) colonization and growth of metastatic tumors. microRNAs (miRNAs) play critical roles in this multi-step process, both promoting and suppressing metastasis. This review updates the progress made in understanding the roles of miRNAs for invasion and metastasis during cancer progression. A specific miRNA signature of cancer metastasis is also reviewed.

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Title: The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade
Authors: Xiao-Feng Le
Omar Merchant
Robert C. Bast Jr.
George A. Calin
Publication date: 01-12-2010
Publisher: Springer Netherlands
Published in: Cancer Microenvironment / Issue 1/2010
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-010-0037-4

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