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MUSCULOSKELETAL SURGERY
Published in: MUSCULOSKELETAL SURGERY 2/2018

01-08-2018 | Original Article

Failed back surgery syndrome: a new strategy by the epidural injection of MESNA

Authors: M. Carassiti, A. Di Martino, A. Centonze, C. C. Quattrocchi, A. Caldaria, F. Agrò, V. Denaro

Published in: MUSCULOSKELETAL SURGERY | Issue 2/2018

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Abstract

Purpose

Evaluate the efficacy and safety of MESNA (sodium 2-mercaptoethanesulfonate) injection into the epidural space in the FBSS.

Methods

We designed a prospective phase II longitudinal study. Six consecutive patients were enrolled. Patients underwent one peridural injection per week for 3 weeks. NRS and ODI were investigated before and 48 h after injections, and at 1 week, 1 month and 2 months after the last procedures. Opioids intake is investigated before procedures and 1 week, 1 month and 3 months after the last procedures. Lumbosacral MRI is performed before the first procedure, at the end and 3 months after the last procedures.

Results

From baseline, at 3 months, NRS in standing, sitting and lying position improved, respectively, of 34.29, 30.56 and 26.47%; ODI improved of 20.3%; the average decrease in morphine intake was 20.54%. No difference in MR images was found. Conclusions Our preliminary results suggest that MESNA might be an efficacy alternative to common practice.
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Metadata
Title
Failed back surgery syndrome: a new strategy by the epidural injection of MESNA
Authors
M. Carassiti
A. Di Martino
A. Centonze
C. C. Quattrocchi
A. Caldaria
F. Agrò
V. Denaro
Publication date
01-08-2018
Publisher
Springer Milan
Published in
MUSCULOSKELETAL SURGERY / Issue 2/2018
Print ISSN: 2035-5106
Electronic ISSN: 2035-5114
DOI
https://doi.org/10.1007/s12306-017-0520-x

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