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MUSCULOSKELETAL SURGERY

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01-12-2013 | Original Article

Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study

Authors: S. Rastogi, S. R. Sankineani, H. L. Nag, S. Mohanty, G. Shivanand, K. Marimuthu, R. Kumar, L. Rijal

Published in: MUSCULOSKELETAL SURGERY | Issue 3/2013

Abstract

Background

Management of early stages of osteonecrosis aims to prevent the collapse of the femoral head by attempts at restoring the vascularity of femoral head. Bone marrow-derived mononuclear cells with their angiogenic and osteogenic properties appear to have the potential to halt the disease process when injected intralesionally following core decompression.

Materials and methods

Forty patients (60 hips) with stage I, II or III (ARCO system) osteonecrosis of femoral head were treated by either core decompression and isolated mononuclear cells (group A) or core decompression and unprocessed bone marrow injection (group B). The patients were followed up clinically and radiologically for a minimum of 2 years. The functional outcome was assessed in terms of Harris hip score, and disease progression was assessed radiologically by comparing the preoperative and follow-up MRI at the end of 2 years.

Results

On 2-year follow-up, there was considerable improvement in the hip function as measured by the Harris hip score in both the groups (p = 0.031). On MRI, there was a decrease in the size of the lesion in group A (p = 0.03). Three of 30 hips (10.0 %) in group B required total hip replacement.

Conclusions

Implantation of autologous bone marrow stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome than bone marrow for early stage of avascular necrosis of femoral head.

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Title: Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study
Authors: S. Rastogi
S. R. Sankineani
H. L. Nag
S. Mohanty
G. Shivanand
K. Marimuthu
R. Kumar
L. Rijal
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: MUSCULOSKELETAL SURGERY / Issue 3/2013
Print ISSN: 2035-5106
Electronic ISSN: 2035-5114
DOI: https://doi.org/10.1007/s12306-013-0273-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study

Abstract

Background

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusions

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