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MUSCULOSKELETAL SURGERY
Published in: MUSCULOSKELETAL SURGERY 1/2011

01-04-2011 | Case Report

Osteoblastic osteosarcoma in monostotic Paget’s disease

Authors: Teresa Calabrò, Andreas F. Mavrogenis, Pietro Ruggieri

Published in: MUSCULOSKELETAL SURGERY | Issue 1/2011

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Abstract

Paget’s disease is a disorder of bone remodelling affecting 1–2% of the general population, most frequently men over 50 years of age. Sarcomatous degeneration occurs in 0.1–0.95% of patients with Paget’s disease. It can be observed in monostotic and polyostotic disease. Osteosarcomas account for more than 80% of pagetic sarcomas; osteoblastic pagetic osteosarcomas are rare. In this article, we present the case of a 75-year-old man with secondary osteosarcoma arising in monostotic Paget’s disease, initially misdiagnosed as rotator cuff tendinopathy. Imaging studies and biopsy were diagnostic.
Literature
1.
Paget J (1877) On a form of chronic inflammation of bones (osteitis deformans). Med Chir Trans 60:37–63PubMed
2.
Roodman GD, Windle JJ (2005) Paget disease of bone. J Clin Invest 115(2):200–208PubMed
3.
Ralston SH, Langston AL, Reid IR (2008) Pathogenesis and management of Paget’s disease of bone. Lancet 372:155–163PubMedCrossRef
4.
Matthews BG, Afzal MA, Minor PD et al (2008) Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget’s disease. J Clin Endocrinol Metab 93(4):1398–1401PubMedCrossRef
5.
Wermers RA, Tiegs RD, Atkinson EJ et al (2008) Morbidity and mortality associated with Paget’s disease of bone: a population-based study. J Bone Miner Res 23(6):819–825PubMedCrossRef
6.
Selby PL, Davie MW, Ralston SH, Stone MD (2006) Guidelines on the management of Paget’s disease of bone. Bone 31(3):366–373CrossRef
7.
Langston AL, Ralston SH (2004) Management of Paget’s disease of bone. Rheumatology (Oxford) 43(8):955–959CrossRef
8.
Mangham DC, Davie MW, Grimer RJ (2009) Sarcoma arising in Paget’s disease of bone: declining incidence and increasing age at presentation. Bone 44:431–436PubMedCrossRef
9.
Huvos AG, Butler A, Bretsky SS (1983) Osteogenic sarcoma associated with Paget’s disease of bone. A clinicopathologic study of 65 patients. Cancer 52(8):1489–1495
10.
Deyrup AT, Montag AG, Inwards CY (2007) Sarcomas arising in Paget disease of bone (a clinicopathologic analysis of 70 cases). Arch Pathol Lab Med 131:942–946PubMed
11.
Hansen M, Seton M (2006) Osteosarcoma in Paget disease of bone. J Bone Miner Res 21(2):58–63CrossRef
12.
Mankin HJ, Hornicek FJ (2005) Paget’s sarcoma: a historical and outcome review. Clin Orthop Relat Res 438:97–102PubMedCrossRef
13.
Malawer MM, Sugarbaker PH (2001) Musculoskeletal Cancer Surgery. Kluwer Academic Publishers; p 179–202
14.
Bacci G, Longhi A, Fagioli F et al (2005) Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27-year experience at Rizzoli Institute, Italy. Eur J Cancer 41:2836–2845PubMedCrossRef
15.
Ferrari S, Smeland S, Mercuri M et al (2005) Italian and Scandinavian Sarcoma Groups neoadjuvant chemotherapy with high-dose ifosfamide, high dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. J Clin Oncol 23:8845–8852PubMedCrossRef
16.
Enneking WF, Dunham W, Gebhardt MC et al (1993) A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res 286:241–246PubMed
17.
Haibach H, Farrell C, Dittrich FJ (1985) Neoplasms arising in Paget’s disease of bone: a study of 82 cases. Am J Clin Pathol 83(5):594–600PubMed
18.
Moore TE, King AR, Kathol MH et al (1991) Sarcoma in Paget disease of bone: clinical, radiologic, and pathologic features in 22 cases. AJR Am J Roentgenol 156(6):1199–1203PubMed
19.
Nellisery MJ, Padalecki SS, Brkanac Z et al (1998) Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone. Am J Hum Genet 63(3):817–824CrossRef
20.
Sun SG, Lau YS, Itonaga I et al (2006) Bone stromal cells in pagetic bone and Paget’s sarcoma express RANKL and support human osteoclast formation. J Pathol 209(1):114–120PubMedCrossRef
21.
Haibach H, Farrell C, Dittrich FJ (1985) Neoplasms arising in Paget’s disease of bone: a study of 82 cases. Am J Clin Pathol 83:594–600PubMed
22.
Monson DK, Finn HA, Dawson PJ, Simon MA (1989) Pseudosarcoma in Paget disease of bone. A case report. J Bone Joint Surg Am 71(3):453–455
23.
Wilgram JW (1977) Radiographical and pathological assessment of the activity of Paget’s disease of bone. Clin Orthop Relat Res 127:43–54PubMed
24.
Lander PH, Hadjipavlou AG (1986) A dynamic classification of Paget’s disease. J Bone Joint Surg Br 68(3):431–438PubMed
25.
Campanacci M (1999) Sarcomas in Paget disease. In: Bone tumors. Padova: Piccin Nuova Libraria SpA; p. 733–736
26.
Lewallen DG (1999) Hip arthroplasty in patients with Paget’s disease. Clin Orthop Relat Res 369:243–250PubMedCrossRef
27.
Merkow RL, Pellicci PM, Hely DP, Salvati EA (1984) Total hip replacement for Paget’s disease of the hip. J Bone Joint Surg Am 66:752–758PubMed
28.
McDonald DJ, Sim FH (1987) Total hip arthroplasty in Paget’s disease. A follow-up note. J Bone Joint Surg Am 69:766–772PubMed
Metadata
Title
Osteoblastic osteosarcoma in monostotic Paget’s disease
Authors
Teresa Calabrò
Andreas F. Mavrogenis
Pietro Ruggieri
Publication date
01-04-2011
Publisher
Springer Milan
Published in
MUSCULOSKELETAL SURGERY / Issue 1/2011
Print ISSN: 2035-5106
Electronic ISSN: 2035-5114
DOI
https://doi.org/10.1007/s12306-011-0100-4

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