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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 4/2019

01-10-2019 | Original Article

Performance Evaluation of Automated Immunohematology Analyzer IH-500 for Blood Bank Testing

Authors: Sang Hyuk Park, Jaewook Kim, Ji-Hun Lim, Joseph Jeong, Seon-Ho Lee

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 4/2019

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Abstract

The automated immunohematology analyzer IH-500 (Bio-rad, Cressier FR, Switzerland) was developed recently for blood bank tests and this study evaluated performance of IH-500. 200 blood samples for ABO/Rh typing were collected. ABO/Rh typing results measured by IH-500 was compared with conventional manual methods. Antibody screening tests were performed with 100 samples using both IH-500 and the Ortho BioVue System, and results were compared. Antibody identification tests were conducted on 5 samples using both IH-500 and the Ortho BioVue System and results were compared. Crossmatching was performed with both IH-500 and conventional manual tube method using 4 patient serum samples and 10 blood cell donors, and 40 results were compared. Isoagglutinin titer of anti-A and anti-B was determined in 10 samples using both IH-500 and the automated analyzer Ortho AutoVue Innova and concordance rates were obtained. The concordance rates of ABO/Rh typing, antibody screening test, antibody identification test, and crossmatching between comparative manual methods and the IH-500 were all 100%. In the evaluation of isoagglutinin titer, 8 (80.0%) results out of 10 samples (80%) showed results within ± 1 titer between the IH-500 and the AutoVue Innova, which indicates the concordance rates of 80.0%. IH-500 reported results with two titers lower than Ortho AutoVue Innova in two samples. The IH-500 demonstrated good concordance rates and provided reliable results compared to comparative manual methods in the blood bank testing. IH-500 would be useful as a possible replacement for conventionally performed manual methods in blood bank testing.
Literature
1.
Brown MR, Fritsma MG, Marques MB (2005) Transfusion safety: what has been done; what is still needed? MLO Med Lab Obs 37(11):20–24PubMed
2.
Davies A, Staves J, Kay J, Casbard A, Murphy MF (2006) End-to-end electronic control of the hospital transfusion process to increase the safety of blood transfusion: strengths and weaknesses. Transfusion 46(3):352–364CrossRef
3.
Stainsby D, Jones H, Asher D, Atterbury C, Boncinelli A, Brand L et al (2006) Serious hazards of transfusion: a decade of hemovigilance in the UK. Transfus Med Rev 20(4):273–282CrossRef
4.
Klouche M (2008) Editorial: impact of automation for testing in transfusion medicine and blood banking. Laboratoriumsmedizin 32(2):57–58CrossRef
5.
Dada A, Beck D, Schmitz G (2007) Automation and data processing in blood banking using the ortho AutoVue® Innova System. Transfus Med Hemother 34:341–346CrossRef
6.
Barkham TM (2004) Laboratory safety aspects of SARS at biosafety level 2. Ann Acad Med Singapore 33(2):252–256PubMed
7.
Butch SH (2008) Automation in the transfusion service. Immunohematology 24(3):86–92PubMed
8.
Sandler SG, Langeberg A, Avery N, Mintz PD (2000) A fully automated blood typing system for hospital transfusion services. ABS2000 study group. Transfusion 40(2):201–207CrossRef
9.
Shin SY, Kwon KC, Koo SH, Park JW, Ko CS, Song JH et al (2008) Evaluation of two automated instruments for pre-transfusion testing: AutoVue Innova and Techno TwinStation. Korean J Lab Med 28(3):214–220CrossRef
10.
Schoenfeld H, Pretzel KJ, von Heymann C, Neuner B, Kalus U, Kiesewetter H et al (2010) Validation of a hospital-laboratory workstation for immunohematologic methods. Transfusion 50(1):26–31CrossRef
11.
Taylor J, Hyare J, Stelfox P, Williams M, Lees R, Maley M (2011) Multi-centre evaluation of pre-transfusional routine tests using 8-column format gel cards (DG Gel®). Transfus Med 21(2):90–98CrossRef
12.
Shin KH, Kim HH, Chang CL, Lee EY (2013) Economic and workflow analysis of a blood bank automated system. Ann Lab Med 33(4):268–273CrossRef
13.
Chang C, Brown M, Davies L, Pointon L, Brown R, Barker D (2014) Evaluation of Erytra® fully automated analyser for routine use in transfusion laboratory. Transfus Med 24(1):33–38CrossRef
14.
Cheng YW, Wilkinson JM (2015) An experience of the introduction of a blood bank automation system (Ortho AutoVue Innova) in a regional acute hospital. Transfus Apher Sci 53(1):58–63CrossRef
15.
Roback JD, Barclay S, Moulds JM, Denomme GA (2015) A multicenter study on the performance of a fully automated, walk-away high-throughput analyzer for pretransfusion testing in the US population. Transfusion 55:1522–1528CrossRef
16.
Shin JW, Shin WY, Lee DL (2017) Comparison of ABO blood group typing between automated blood bank analyzer IH-500 and manual method. Korean J Blood Transfus 28(2):126–133CrossRef
17.
Park YM, Kim SY, Koo SH, Lim J, Kim JM, Lim YA (2017) Evaluation of the automated blood bank systems IH-500 and VISION max for ABO-RhD blood typing and unexpected antibody screening. Lab Med Online 7(4):170–175CrossRef
18.
Morelati F, Revelli N, Maffei LM, Poretti M, Santoro C, Parravicini A (1998) Evaluation of a new automated instrument for pretransfusion testing. Transfusion 38(10):959–965CrossRef
Metadata
Title
Performance Evaluation of Automated Immunohematology Analyzer IH-500 for Blood Bank Testing
Authors
Sang Hyuk Park
Jaewook Kim
Ji-Hun Lim
Joseph Jeong
Seon-Ho Lee
Publication date
01-10-2019
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 4/2019
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-019-01127-4

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