Skip to main content
Top
Published in: Indian Journal of Hematology and Blood Transfusion 1/2014

01-09-2014 | Case Report

Juvenile Myelomonocytic Leukemia in India: Cure Remains a Distant Dream!

Authors: Mohammed Ramzan, Satya Prakash Yadav, Nivedita Dhingra, Anupam Sachdeva

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2014

Login to get access

Abstract

There is paucity of outcome data regarding juvenile myelomonocytic leukemia from India. We report a series of eight children. Three had monosomy 7 and one had complex cytogenetics. One with Down’s syndrome recovered spontaneously. Three refused therapy of whom only one is alive with disease. One died post chemotherapy. Three underwent allogeneic stem cell transplant after protracted delay with funds arranged from various governmental and non-governmental organizations. Of these two died (relapse-1 and intracranial bleed-1) and one is alive and disease free. In India, it’s a milestone to reach transplant due to high cost and cure still remains a distant dream.
Literature
1.
go back to reference Niemeyer CM, Arico M, Basso G, Biondi A, Cantu Rajnoldi A, Creutzig U et al (1997) Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood 89:3534–3543PubMed Niemeyer CM, Arico M, Basso G, Biondi A, Cantu Rajnoldi A, Creutzig U et al (1997) Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood 89:3534–3543PubMed
2.
go back to reference Emanual PD (1999) Myelodysplasia and myeloproliferative disorders in childhood: an update. Br J Haematol 105:852–863CrossRef Emanual PD (1999) Myelodysplasia and myeloproliferative disorders in childhood: an update. Br J Haematol 105:852–863CrossRef
3.
go back to reference Arico M, Biondi A, Pui CH (1997) Juvenile myelomonocytic leukaemia. Blood 90:479–488PubMed Arico M, Biondi A, Pui CH (1997) Juvenile myelomonocytic leukaemia. Blood 90:479–488PubMed
4.
go back to reference Chan RJ, Cooper T, Kratz CP et al (2009) Juvenile myelomonocytic leukemia: a report from the 2nd international JMML symposium. Leuk Res 33(3):355–362PubMedCrossRefPubMedCentral Chan RJ, Cooper T, Kratz CP et al (2009) Juvenile myelomonocytic leukemia: a report from the 2nd international JMML symposium. Leuk Res 33(3):355–362PubMedCrossRefPubMedCentral
5.
go back to reference Locatelli F, Nollke P, Zecca M et al (2005) Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood 105:410–419PubMedCrossRef Locatelli F, Nollke P, Zecca M et al (2005) Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood 105:410–419PubMedCrossRef
6.
go back to reference Manabe A, Okamura J, Yumura-Yagi K et al (2002) Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the international JMML Working Group. Leukemia 16:645–649PubMedCrossRef Manabe A, Okamura J, Yumura-Yagi K et al (2002) Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the international JMML Working Group. Leukemia 16:645–649PubMedCrossRef
7.
go back to reference Crombet O, Svarch E (1999) Down syndrome and Juvenile myelomonocytic leukemia. Pediatr Hematol Oncol 16(2):181–182PubMedCrossRef Crombet O, Svarch E (1999) Down syndrome and Juvenile myelomonocytic leukemia. Pediatr Hematol Oncol 16(2):181–182PubMedCrossRef
8.
go back to reference Arya LS, Bhatia P, Jain Y, Choudhry VP, Verma IC, Chinnappan D, Pati HP (1995) Juvenile chronic myelocytic leukemia-report of ten cases. Med Pediatr Oncol 24:100–103PubMedCrossRef Arya LS, Bhatia P, Jain Y, Choudhry VP, Verma IC, Chinnappan D, Pati HP (1995) Juvenile chronic myelocytic leukemia-report of ten cases. Med Pediatr Oncol 24:100–103PubMedCrossRef
9.
go back to reference Puri K, Singh S, Das RR, Seth R, Gupta R (2011) Diagnostic dilemma of JMML coexisting with CMV infection. Indian J Pediatr 78(4):485–487PubMedCrossRef Puri K, Singh S, Das RR, Seth R, Gupta R (2011) Diagnostic dilemma of JMML coexisting with CMV infection. Indian J Pediatr 78(4):485–487PubMedCrossRef
10.
go back to reference Gupta N, Gupta R, Sharawat SK, Bakhshi S (2010) Childhood chronic myeloid leukemia with monocytosis. Indian J Pediatr 77:1143–1145PubMedCrossRef Gupta N, Gupta R, Sharawat SK, Bakhshi S (2010) Childhood chronic myeloid leukemia with monocytosis. Indian J Pediatr 77:1143–1145PubMedCrossRef
11.
go back to reference Locatelli F, Madureira A, Rocha V et al (2007) Unrelated cord blood transplantation for children with juvenile myelomonocytic leukemia [abstract no. 2021]. Blood 110(11):602a72 Locatelli F, Madureira A, Rocha V et al (2007) Unrelated cord blood transplantation for children with juvenile myelomonocytic leukemia [abstract no. 2021]. Blood 110(11):602a72
Metadata
Title
Juvenile Myelomonocytic Leukemia in India: Cure Remains a Distant Dream!
Authors
Mohammed Ramzan
Satya Prakash Yadav
Nivedita Dhingra
Anupam Sachdeva
Publication date
01-09-2014
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2014
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-014-0434-9

Other articles of this Special Issue 1/2014

Indian Journal of Hematology and Blood Transfusion 1/2014 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine