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Breast Cancer
Published in: Breast Cancer 3/2013

01-07-2013 | Original Article

Sentinel lymph node biopsy in patients with breast cancer using superparamagnetic iron oxide and a magnetometer

Authors: Mikio Shiozawa, Alan T. Lefor, Yasuo Hozumi, Katsumi Kurihara, Naohiro Sata, Yoshikazu Yasuda, Moriaki Kusakabe

Published in: Breast Cancer | Issue 3/2013

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Abstract

Background

Some hospitals lack facilities for radioisotopes in sentinel node biopsy. A novel method is used with a superparamagnetic tracer and a magnetometer instead of a radioisotope.

Methods

Thirty patients were included in the study after obtaining IRB approval. Superparamagnetic iron oxide and patent blue dye were injected in the subareolar breast tissue. Following a few minutes of massage to promote migration of the iron tracer and blue dye throughout the lymphatic vessels, the axillary lymph nodes were detected transdermally using a handheld magnetometer and followed by standard axillary dissection in all patients.

Results

Of 30 patients evaluated, sentinel lymph nodes were identified in 90% (27/30) using both blue dye and magnetic tracer. Sentinel lymph nodes were identified using the magnetic method in 23/30 (77%) and blue dye in 24/30 (80%). There was one false-negative sentinel node, resulting in an overall sensitivity of 6/7 (86%).

Conclusions

This is the first study to use a magnetic tracer to identify sentinel lymph nodes in patients with breast cancer. This new technique may alter the role of radioisotopes with further refinement and experience.
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Metadata
Title
Sentinel lymph node biopsy in patients with breast cancer using superparamagnetic iron oxide and a magnetometer
Authors
Mikio Shiozawa
Alan T. Lefor
Yasuo Hozumi
Katsumi Kurihara
Naohiro Sata
Yoshikazu Yasuda
Moriaki Kusakabe
Publication date
01-07-2013
Publisher
Springer Japan
Published in
Breast Cancer / Issue 3/2013
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-011-0327-9

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