Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Breast Cancer
Published in: Breast Cancer 2/2014

01-03-2014 | Case Report

Primary amelanotic melanoma of the breast: combating a rare cancer

Authors: Ahitagni Biswas, Shikha Goyal, Ayushi Jain, Vaishali Suri, Sandeep Mathur, Pramod Kumar Julka, Goura Kishor Rath

Published in: Breast Cancer | Issue 2/2014

Login to get access

Abstract

Background

Malignant melanoma is the foremost cause of metastasis to the breast from extramammary solid neoplasm. However primary melanoma of the breast is a distinct rarity. Primary melanoma involves the skin and less commonly the glandular parenchyma of the breast.

Method

We herein describe a case of primary amelanotic melanoma of the breast parenchyma in a 32-year-old female managed with a combination of surgery, adjuvant radiotherapy and immunotherapy.

Conclusion

This case report aims to increase awareness of unusual neoplasms of the breast which might require a different surgical and adjuvant therapeutic approach.
Literature
1.
Kurul S, Tas F, Buyukbabani N, Mudun A, Baykal C, Camlica H. Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of literature. Jpn J Clin Oncol. 2005;34:202–6.CrossRef
2.
3.
Roy S, Dhingra K, Mandal S, Khurana N. Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump. Melanoma Res. 2008;18:447–50.PubMedCrossRef
4.
Ruffolo EF, Koerner FC, Maluf HM. Metaplastic carcinoma of the breast with melanocytic differentiation. Mod Pathol. 1997;10:592–6.PubMed
5.
Yen H, Florentine B, Kelly LK, Bu X, Crawford J, Martin SE. Fine needle aspiration of a metaplastic breast carcinoma with extensive melanocytic differentiation: a case report. Diagn Cytopathol. 2000;23:46–50.PubMedCrossRef
6.
Nobukawa B, Fujii H, Hirai S, Kumasaka T, Shimizu H, Matsumoto T, et al. Breast carcinoma diverging to aberrant melanocytic differentiation: a case report with histopathologic and loss of heterozygosity analyses. Am J Surg Pathol. 1999;23:1280–7.PubMedCrossRef
7.
Mitchell S, Lachica R, Randall MB, Beech DJ. Paget’s disease of the breast areola mimicking cutaneous melanoma. Breast J. 2006;12:233–6.PubMedCrossRef
8.
Pizzichetta MA, Canzonieri V, Massarut S, Gloghini A, Trevisan G, Veronesi A, et al. Pigmented mammary Paget’s disease mimicking melanoma. Melanoma Res. 2004;14:S13–5.PubMedCrossRef
9.
Williams SA, Ehlers RA, Hunt KK, Min Y, Kuerer HM, Singletary SE, et al. Metastases to breast from nonbreast solid neoplasms. Presentation and determinants of survival. Cancer. 2007;110:731–7.PubMedCrossRef
10.
Vaughan A, Dietz JR, Moley JF, De Benedetti MK, Aft RL, Gillanders WE, et al. Metastatic disease to the breast: the Washington University experience. World J Surg Oncol. 2007;5:74.PubMedCentralPubMedCrossRef
11.
Ravdel L, Robinson WA, Lewis K, Gonzalez R. Metastatic melanoma in the breast: a report of 27 cases. J Surg Oncol. 2006;94:101–4.PubMedCrossRef
12.
Ewing CA, Miller MJ, Chhieng D, Lin O. Nonepithelial malignancies mimicking primary carcinoma of the breast. Diagn Cytopathol. 2004;31:352–7.PubMedCrossRef
13.
Hancock C, Allen BC, Herrera GA. HMB-45 detection in adenocarcinomas. Arch Pathol Lab Med. 1991;115(9):886–90.PubMed
14.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol. 2008;35(5):433–44.PubMedCrossRef
15.
Filie AC, Simsir A, Fetsch P, Abati A. Melanoma metastatic to the breast: utility of fine needle aspiration and immunohistochemistry. Acta Cytol. 2002;46:13–8.PubMedCrossRef
16.
Govender D, Sabaratnam RM, Essa AS. Clear cell ‘sugar’ tumor of the breast: another extrapulmonary site and review of the literature. Am J Surg Pathol. 2002;26:670–5.PubMedCrossRef
17.
Damiani S, Chiodera P, Guaragni M, Eusebi V. Mammary angiomyolipoma. Virchows Arch. 2002;440:551–2.PubMedCrossRef
18.
Thompson JF, McCarthy WH, Bosch CM, O’Brien CJ, Quinn MJ, Paramaesvaran S, et al. Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes. Melanoma Res. 1995;5:255–60.PubMedCrossRef
19.
Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intra-operative lymphatic mapping for early melanoma. Arch Surg. 1992;127:392–9.PubMedCrossRef
20.
Calabro A, Singletary SE, Balch CM. Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg. 1989;124:1051–5.PubMedCrossRef
21.
Lee RJ, Gibbs JF, Proulx GM, Kollmorgen DR, Jia C, Kraybill WG. Nodal basin recurrence following lymph node dissection for melanoma: implications for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2000;46:467–74.PubMedCrossRef
22.
Sause WT, Cooper JS, Rush S, Ago CT, Cosmatos D, Couglin CT, et al. Fraction size in external beam radiotherapy in the treatment of melanoma. Int J Radiat Oncol Biol Phys. 1991;20:429–32.PubMedCrossRef
23.
Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U, Eastern Cooperative Oncology Group. A pooled analysis of Eastern Cooperative Oncology Group and Intergroup trials of adjuvant high dose interferon for melanoma. Clin Cancer Res. 2004;10:1670–7.PubMedCrossRef
Metadata
Title
Primary amelanotic melanoma of the breast: combating a rare cancer
Authors
Ahitagni Biswas
Shikha Goyal
Ayushi Jain
Vaishali Suri
Sandeep Mathur
Pramod Kumar Julka
Goura Kishor Rath
Publication date
01-03-2014
Publisher
Springer Japan
Published in
Breast Cancer / Issue 2/2014
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-010-0231-8

Other articles of this Issue 2/2014

Breast Cancer 2/2014 Go to the issue

Author's Reply

In reply: Maspin and it’s evolving role in tumor progression in systemic malignancies

Original Article

Feasibility of prior administration of cyclophosphamide in TC combination treatment

Original Article

Opportunistic breast cancer screening by mammography in Japan for women in their 40s at our preventive medical center: harm or benefit?

Original Article

Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo

Original Article

Underestimation of papillary breast lesions by core biopsy: correlation to surgical excision

Original Article

Marked lymphovascular invasion, progesterone receptor negativity, and high Ki67 labeling index predict poor outcome in breast cancer patients treated with endocrine therapy alone
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits