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Indian Journal of Surgery
Published in: Indian Journal of Surgery 1/2016

01-02-2016 | Review Article

Extraosseous Ewing Sarcoma: Diagnosis, Prognosis and Optimal Management

Authors: George Galyfos, Georgios A. Karantzikos, Nikolaos Kavouras, Argiri Sianou, Konstantinos Palogos, Konstantinos Filis

Published in: Indian Journal of Surgery | Issue 1/2016

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Abstract

Extraosseous Ewing sarcomas (EESs) are rare tumours originating from soft tissues. Their clinical picture depends mainly on the primary site of the sarcoma. Patient characteristics and outcomes seem to be different in EES compared to patients with skeletal Ewing sarcoma, with implications for patient care and prognosis. However, multimodality therapeutic strategies are recommended for all types of the Ewing tumour family. The available diagnostic tools include ultrasonographic evaluation and computed tomography (CT) or magnetic resonance imaging as well as histopathologic and immunohistochemical tissue examination. Several histologic and genetic biomarkers have been established, although their utilization needs to be further tested by larger prospective studies. Regarding localized disease, the recommended treatment remains surgery. However, chemotherapy can be added to achieve improved survival, with neoadjuvant regimens showing more promising results than adjuvant regimens. Radiotherapy is an option to obtain local control, although its complications have reduced its utilization. In metastatic or recurrent disease, systematic chemotherapy improves survival.
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Metadata
Title
Extraosseous Ewing Sarcoma: Diagnosis, Prognosis and Optimal Management
Authors
George Galyfos
Georgios A. Karantzikos
Nikolaos Kavouras
Argiri Sianou
Konstantinos Palogos
Konstantinos Filis
Publication date
01-02-2016
Publisher
Springer India
Published in
Indian Journal of Surgery / Issue 1/2016
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI
https://doi.org/10.1007/s12262-015-1399-0

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