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01-06-2013 | Original Article

Morphometric and Histological Study of Breast Lesions with Special Reference to Proliferative Activity and Invasiveness

Authors: Asim Kumar Manna, Aparajita Samaddar, Sumit Mitra, Swapan Pathak, Srabani Chakrabarti, Diptendra Kumar Sarkar

Published in: Indian Journal of Surgery | Issue 3/2013

Abstract

Breast carcinoma is the most common cause of carcinoma death in women. Sometimes, difficulty arises to differentiate between premalignant lesions and carcinoma by routine histopathology. Our study was done to establish the role of morphometry and immunohistochemistry to solve this problem. In this study, total 60 cases of different breast lesions were included and 10 controls were also included to compare the results with the normal findings. They were studied by hematoxylin and eosin-stained sections for morphometry and routine histological study; as well as by proliferative markers such as proliferating cell nuclear antigen and p53. Invasiveness was studied using immunohistochemical staining with 34 βE12 monoclonal antibody. Statistically significant differences were found in morphometric parameters and in expression of proliferative markers between most of them. Morphometry and immunohistochemistry help in the proper diagnosis of different breast lesions that lie in the gray zone on routine histopathology.

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Title: Morphometric and Histological Study of Breast Lesions with Special Reference to Proliferative Activity and Invasiveness
Authors: Asim Kumar Manna
Aparajita Samaddar
Sumit Mitra
Swapan Pathak
Srabani Chakrabarti
Diptendra Kumar Sarkar
Publication date: 01-06-2013
Publisher: Springer India
Published in: Indian Journal of Surgery / Issue 3/2013
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI: https://doi.org/10.1007/s12262-012-0486-8

At a glance: The STEP trials

Springer Medicine

Morphometric and Histological Study of Breast Lesions with Special Reference to Proliferative Activity and Invasiveness

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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