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memo - Magazine of European Medical Oncology
Published in: memo - Magazine of European Medical Oncology 2/2018

01-06-2018 | review

JAK2V617F allele burden: innovative concept in monitoring of myeloproliferative neoplasms

Authors: Soheila Bagheropur, Ali Ehsanpour, Maryam Tahmasebi Birgani, Najmaldin Saki

Published in: memo - Magazine of European Medical Oncology | Issue 2/2018

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Summary

Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are characterized by mutations in genes, such as JAK2V617F, JAK2 exon12 gene and MPL. With respect to MPN-associated subclasses, each of these disorders has a different allele burden during disease treatment. Up to now, several studies have been conducted on the relationship between allele burden with specific MPN-associated phenotypic features, prognosis and disease progression. It seems that finding such a correlation would be a great contribution to faster diagnosis and effective treatment. The goal of this review is to investigate the relationship between JAK2V617 allele burden with different MPN subtypes and their different phenotypes. Allele burden is closely associated with MPN phenotype and can partially indicate the prognosis, progression and even the likelihood of disease transformation.
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Metadata
Title
JAK2V617F allele burden: innovative concept in monitoring of myeloproliferative neoplasms
Authors
Soheila Bagheropur
Ali Ehsanpour
Maryam Tahmasebi Birgani
Najmaldin Saki
Publication date
01-06-2018
Publisher
Springer Vienna
Published in
memo - Magazine of European Medical Oncology / Issue 2/2018
Print ISSN: 1865-5041
Electronic ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-018-0397-x

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