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Pathology & Oncology Research
Published in: Pathology & Oncology Research 2/2020

01-04-2020 | Acute Myeloid Leukemia | Letter to the Editor

Intravascular Occlusion by Leukemic Blast Cells Causing Multiplex Hand Necrosis in a Patient with Acute Myeloid Leukemia

Authors: László Pinczés, Ferenc Magyari, Gyula Reményi, György Pfliegler, Sándor Barna, Judit Bedekovics, Árpád Illés

Published in: Pathology & Oncology Research | Issue 2/2020

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Excerpt

In April 2017, a 76 years old female patient with a history of hypertension, hypothyreosis and left renal artery stenosis was diagnosed with acute myeloid leukemia (AML; FAB M4). She presented with poor prognostic markers including complex karyotype with wild-type FLT-3 and NPM-1 mutations. After induction chemotherapy (3 + 7 regimen, consisting 60 mg/m2 of daunorubicin and 100 mg/m2 of cytosine arabinoside) she experienced treatment failure with progressive disease and newly detected peripheral blast cells. After receiving dismal results she withdrew consent for further treatment. …
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Thépot S, Itzykson R, Seegers V, Recher C, Raffoux E, Quesnel B, Delaunay J, Cluzeau T, Marfaing Koka A, Stamatoullas A, Chaury MP, Dartigeas C, Cheze S, Banos A, Morel P, Plantier I, Taksin AL, Marolleau JP, Pautas C, Thomas X, Isnard F, Beve B, Chait Y, Guerci A, Vey N, Dreyfus F, Ades L, Ifrah N, Dombret H, Fenaux P, Gardin C, On behalf of the Groupe Francophone des Myélodysplasies (GFM), the Acute Leukemia French Association (ALFA); the Groupe Ouest-Est des Leucémies Aiguës; Maladies du Sang (GOELAMS) (2014) Azacitidine in untreated acute myeloid leukemia: a report on 149 patients. Am J Hematol 89:410–416. https://​doi.​org/​10.​1002/​ajh.​23654 CrossRefPubMed
Metadata
Title
Intravascular Occlusion by Leukemic Blast Cells Causing Multiplex Hand Necrosis in a Patient with Acute Myeloid Leukemia
Authors
László Pinczés
Ferenc Magyari
Gyula Reményi
György Pfliegler
Sándor Barna
Judit Bedekovics
Árpád Illés
Publication date
01-04-2020
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 2/2020
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-019-00636-x

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