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Published in: Pathology & Oncology Research 4/2019

01-10-2019 | Colorectal Cancer | Original Article

GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer

Authors: Zheng Liu, Ming Yang, Song Wang, Hai-peng Chen, Xu Guan, Zhi-xun Zhao, Zheng Jiang, Ji-chuan Quan, Run-kun Yang, Xi-shan Wang

Published in: Pathology & Oncology Research | Issue 4/2019

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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. GGN is a germ cell-specific gene, but its function in CRC has been rarely reported to date. The aim of this study was to investigate the potential role of GGN in CRC tumorigenesis. Therefore, in this study, we examined the expression of GGN in CRC cell lines and tissues and its effects on cellular proliferation and apoptosis. We then explored the underlying mechanism. Our results showed that GGN was significantly overexpressed in both CRC cell lines and tissues. Silencing GGN robustly inhibited proliferation of CRC cells, and it also promoted apoptosis of CRC cells. Moreover, knockdown of GGN inhibited the expression of p-Akt in CRC cells. Taken together, these results showed that knockdown of GGN inhibits proliferation and promotes apoptosis of CRC cells through the PI3K/Akt signaling pathway. Our findings revealed for the first time a potential oncogenic role for GGN in CRC progress. This finding may provide a unique perspective on how a germ cell-specific gene might serve as a biomarker, or even as a therapeutic target, for CRC.
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Metadata
Title
GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer
Authors
Zheng Liu
Ming Yang
Song Wang
Hai-peng Chen
Xu Guan
Zhi-xun Zhao
Zheng Jiang
Ji-chuan Quan
Run-kun Yang
Xi-shan Wang
Publication date
01-10-2019
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 4/2019
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-019-00595-3

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