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01-10-2018 | Review Paper

The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications

Authors: Pingping Guo, Wenqi Chen, Huiyu Li, Meiying Li, Lisha Li

Published in: Pathology & Oncology Research | Issue 4/2018

Abstract

The histone acetylation modifications (HAMs) influence a large number of cellular functions. They are mediated through histone acetyltransferase (HAT) and histone deacetylase (HDAC). Nowadays, people have realized that HAMs are crucial for development and prognosis of breast cancer. Investigations about abnormal HAMs in breast cancer focus on initiating molecular mechanisms in breast cancer development, identification of new biomarkers to predict breast cancer aggressiveness and the therapeutic potential. As HAMs are reversible, breast cancer may be treated by restoring HAMs to normal levels. Indeed, some HDAC inhibitors have been approved by the US Food and Drug Administration to treat certain cancers. Furthermore, HAT inhibitors, HAT activators and HDAC activators may also be used as drugs to treat breast cancer.

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Title: The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications
Authors: Pingping Guo
Wenqi Chen
Huiyu Li
Meiying Li
Lisha Li
Publication date: 01-10-2018
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 4/2018
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-018-0433-5

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