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01-07-2018 | Review

The Tumor Entity Denominated “clear cell-papillary renal cell carcinoma” According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome

Authors: Francesco Massari, Chiara Ciccarese, Ondrej Hes, Michal Michal, Anna Caliò, Michelangelo Fiorentino, Francesca Giunchi, Alessandro D’Amuri, Francesca Sanguedolce, Roberto Sabbatini, Annalisa Guida, Andrea Ardizzoni, Camillo Porta, Roberto Iacovelli, Giampaolo Tortora, Luca Cima, Cinzia Ortega, Alberto Lapini, Guido Martignoni, Matteo Brunelli

Published in: Pathology & Oncology Research | Issue 3/2018

Abstract

The new WHO 2016 classification of renal neoplasia encounters the new entity called “clear cell papillary renal cell carcinoma” (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histotype and it actually ranges from 2 to 9% in different routinely available cohort of renal carcinomas. Of important note, ccpRCC does not show any recurrences or metastases or lymph-node invasion and the outcome is always good. We reviewed twenty-four publications with available follow-up for patients (no. 362) affected by clear cell papillary RCCs/renal adenomatoid tumours and notably ccpRCC harbors an indolent clinical behavior after a mean of 38 months (3,5 years) of follow-up. This paper reviews the histological, molecular and clinical features characterizing ccpRCC, with the goal of focusing the knowledge of the benign fashion of this new tumour entity, supporting the idea of a new renal cell adenoma recruited morphologically from ex conventional clear cell RCC tumours.

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Title: The Tumor Entity Denominated “clear cell-papillary renal cell carcinoma” According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome
Authors: Francesco Massari
Chiara Ciccarese
Ondrej Hes
Michal Michal
Anna Caliò
Michelangelo Fiorentino
Francesca Giunchi
Alessandro D’Amuri
Francesca Sanguedolce
Roberto Sabbatini
Annalisa Guida
Andrea Ardizzoni
Camillo Porta
Roberto Iacovelli
Giampaolo Tortora
Luca Cima
Cinzia Ortega
Alberto Lapini
Guido Martignoni
Matteo Brunelli
Publication date: 01-07-2018
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 3/2018
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-017-0271-x

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