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Pathology & Oncology Research

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01-04-2017 | Letter to the Editor

WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers

Authors: Ju Hwa Lee, Sung Soo Kim, Min Sung Kim, Nam Jin Yoo, Sug Hyung Lee

Published in: Pathology & Oncology Research | Issue 2/2017

Excerpt

To the Editor …

Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M (2008) Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. Cancer Sci 99:843–848CrossRefPubMed

Goto M, Miller RW, Ishikawa Y, Sugano H (1996) Excess of rare cancers in Werner syndrome (adult progeria) (1996) J. Cancer Epidemiol Biomark Prev 5:239–246

Shimamoto A, Sugimoto M, Furuichi Y (2004) Molecular biology of Werner syndrome 2004. Int J Clin Oncol 9:288–298CrossRefPubMed

Yamagata K, Kato J, Shimamoto A, Goto M, Furuichi Y, Ikeda H (1998) Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A 95:8733–8738CrossRefPubMedPubMedCentral

Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680CrossRefPubMed

Choi MR, Gwak M, Yoo NJ, Lee SH (2015) Regional bias of Intratumoral genetic heterogeneity of apoptosis-related genes BAX, APAF1, and FLASH in Colon cancers with high microsatellite instability. Dig Dis Sci 60:1674–1679CrossRefPubMed

Kim TM, Jung SH, An CH, Lee SH, Baek IP, Kim MS, Park SW, Rhee JW, Lee SH, Chung YJ (2015) Subclonal genomic architectures of primary and metastatic colorectal cancer based on Intratumoral genetic heterogeneity. Clin Cancer Res 21:4461–4472CrossRefPubMed

Title: WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers
Authors: Ju Hwa Lee
Sung Soo Kim
Min Sung Kim
Nam Jin Yoo
Sug Hyung Lee
Publication date: 01-04-2017
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 2/2017
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-016-0173-3

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