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01-10-2016 | Original Article

NDRG1 Controls Gastric Cancer Migration and Invasion through Regulating MMP-9

Authors: Xiaojing Chang, Xiaoyang Xu, Xiaoying Xue, Jinguo Ma, Zhenhua Li, Peng Deng, Jing Chen, Shuanglong Zhang, Yu Zhi, Dongqiu Dai

Published in: Pathology & Oncology Research | Issue 4/2016

Abstract

The purpose of this study is to detect the clinical significance of NDRG1 and its relationship with MMP-9 in gastric cancer metastatic progression. 101 cases of gastric cancer specimens were utilized to identify the protein expression of NDRG1 and MMP-9 by immunohistochemistry, their clinical significance was also analyzed. The suppression by siRNA-NDRG1 was employed to detect the role of NDRG1 in gastric cancer progression and its relationship with MMP-9. NDRG1 expression was correlated inversely with the degree of tumor cell differentiation (p < 0.01), invasion depth (p < 0.05), lymph node metastasis (p < 0.05) and TNM stage (p < 0.05), whereas MMP-9 was positive correlated with the degree of tumor cell differentiation (p < 0.01), lymph node metastasis (p < 0.05) and TNM stage (p < 0.05), but not correlated with invasion depth (p>0.05). Furthermore, cell proliferation and invasion effect were remarkably enhanced when NDRG1 was silencing, but MMP-9 expression was increased. NDRG1 silencing enhances gastric cancer cells progression through upregulating MMP-9. It suggests that NDRG1 may inhibit the metastasis of gastric cancer via regulating MMP-9.

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Title: NDRG1 Controls Gastric Cancer Migration and Invasion through Regulating MMP-9
Authors: Xiaojing Chang
Xiaoyang Xu
Xiaoying Xue
Jinguo Ma
Zhenhua Li
Peng Deng
Jing Chen
Shuanglong Zhang
Yu Zhi
Dongqiu Dai
Publication date: 01-10-2016
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 4/2016
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-016-0071-8

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