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Pathology & Oncology Research
Published in: Pathology & Oncology Research 3/2009

01-09-2009 | Original Paper

Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

Authors: Zhi-Bo Zhang, Lei Cai, Shu-Guo Zheng, Yan Xiong, Jia-Hong Dong

Published in: Pathology & Oncology Research | Issue 3/2009

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Abstract

Caveolin-1 is the major structural protein in caveolae, implicated in oncogenesis and angiogenesis. The connections between caveolin-1 and progression and angiogenesis of hepatocellular carcinoma (HCC) is still not clear. Thus we investigated the relationship of caveolin-1 expression, vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and unpaired artery (UA) with the clinicopathologic features of patients with HCC. Formalin-fixed, paraffin-embedded tissue sections of HCC from 75 patients who had undergone an initial hepatectomy were stained immunohistochemically with specific antibodies against caveolin-1, VEGF, CD34 and α-SMA. The levels of caveolin-1, VEGF, MVD and UA were correlated with the clinicopathologic variables, and tissue sections were also analyzed by dual-label immunofluorescence. We found that increased expression of caveolin-1 was associated with metastasis and with a worse prognosis of HCC. Caveolin-1 expression correlates positively with VEGF, MVD and UA. These results suggest that caveolin-1 may play an important role in the progression of HCC and angiogenesis.
Literature
1.
Okamoto T, Schlegel A, Scherer PE, Lisanti MP (1998) Caveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membrane. J Biol Chem 273:5419–5422CrossRefPubMed
2.
Wikman H, Kettunen E, Seppänen JK, Karjalainen A, Hollmén J, Anttila S, Knuutila S (2002) Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array. Oncogene 21:5804–5813CrossRefPubMed
3.
Wiechen K, Sers C, Agoulnik A, Arlt K, Dietel M, Schlag PM, Schneider U (2001) Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Am J Pathol 158:833–839PubMed
4.
Kato K, Hida Y, Miyamoto M, Hashida H, Shinohara T, Itoh T, Okushiba S, Kondo S, Katoh H (2002) Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer 94:929–933CrossRefPubMed
5.
Suzuoki M, Miyamoto M, Kato K, Hiraoka K, Oshikiri T, Nakakubo Y, Fukunaga A, Shichinohe T, Shinohara T, Itoh T, Kondo S, Katoh H (2002) Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. Br J Cancer 87:1140–1144CrossRefPubMed
6.
Rajjayabun PH, Garg S, Durkan GC, Charlton R, Robinson MC, Mellon JK (2001) Caveolin-1 expression is associated with high-grade bladder cancer. Urology 58:811–814CrossRefPubMed
7.
Dewever J, Frérart F, Bouzin C, Baudelet C, Ansiaux R, Sonveaux P, Gallez B, Dessy C, Feron O (2007) Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment. Am J Pathol 171:1619–1628CrossRefPubMed
8.
Joo HJ, Oh DK, Kim YS, Lee KB, Kim SJ (2004) Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int 93:291–296CrossRefPubMed
9.
Anders RA, Yerian LM, Tretiakova M, Davison JM, Quigg RJ, Domer PH, Hoberg J, Hart J (2003) cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis. Am J Pathol 162:991–1000PubMed
10.
Hirasawa Y, Arai M, Imazeki F, Tada M, Mikata R, Fukai K, Miyazaki M, Ochiai T, Saisho H, Yokosuka O (2006) Methylation status of genes upregulated by demethylating agent 5-aza-2′-deoxycytidine in hepatocellular carcinoma. Oncology 71:77–85PubMed
11.
Zhou H, Jia L, Wang S, Wang H, Chu H, Hu Y, Cao J, Zhang J (2006) Divergent expression and roles for caveolin-1 in mouse hepatocarcinoma cell lines with varying invasive ability. Biochem Biophys Res Commun 345:486–494CrossRefPubMed
12.
Choi HN, Kim KR, Park HS, Jang KY, Kang MJ, Lee DG, Kim YK, Cho BH, Cha EJ, Moon WS (2007) Expression of caveolin in hepatocellular carcinoma: association with unpaired artery formation and radiologic findings. Korean J Hepatol 13:396–408CrossRefPubMed
13.
Park SS, Kim JE, Kim YA, Kim YC, Kim SW (2005) Caveolin-1 is down-regulated and inversely correlated with HER2 and EGFR expression status in invasive ductal carcinoma of the breast. Histopathology 47:625–630CrossRefPubMed
14.
Tanigawa N, Lu C, Mitsui T, Miura S (1997) Quantitation of sinusoid-like vessels in hepatocellular carcinoma: its clinical and prognostic significance. Hepatology 26:1216–1223PubMed
15.
Glenney JR Jr (1989) Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus. J Biol Chem 264:20163–20166PubMed
16.
Williams TM, Medina F, Badano I, Hazan RB, Hutchinson J, Muller WJ, Chopra NG, Scherer PE, Pestell RG, Lisanti MP (2004) Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. J Biol Chem 279:51630–51646CrossRefPubMed
17.
Yang G, Addai J, Wheeler TM, Frolov A, Miles BJ, Kadmon D, Thompson TC (2007) Correlative evidence that prostate cancer cell-derived caveolin-1 mediates angiogenesis. Hum Pathol 38:1688–1695CrossRefPubMed
18.
Barresi V, Cerasoli S, Paioli G, Vitarelli E, Giuffrè G, Guiducci G, Tuccari G, Barresi G (2006) Caveolin-1 in meningiomas: expression and clinico-pathological correlations. Acta Neuropathol 112:617–626CrossRefPubMed
19.
Bailey KM, Liu J (2008) Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem 283:13914–13724CrossRef
20.
Barresi V, Cerasoli S, Tuccari G (2008) Correlative evidence that tumor cell-derived caveolin-1 mediates angiogenesis in meningiomas. Neuropathology 28:472–478CrossRefPubMed
21.
Yerian LM, Anders RA, Tretiakova M, Hart J (2004) Caveolin and thrombospondin expression during hepatocellular carcinogenesis. Am J Surg Pathol 28:357–364CrossRefPubMed
22.
Mitsuhashi N, Shimizu H, Ohtsuka M, Wakabayashi Y, Ito H, Kimura F, Yoshidome H, Kato A, Nukui Y, Miyazaki M (2003) Angiopoietines and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology 37:1105–1113CrossRefPubMed
23.
Morinaga S, Imada T, Shimizu A, Akaike M, Sugimasa Y, Takemiya S, Takanashi Y (2001) Angiogenesis in hepatocellular carcinoma as evaluated by alpha smooth muscle actin immunohistochemistry. Hepatogastroenterology 48:224–228PubMed
24.
Liu J, Wang XB, Park DS, Lisanti MP (2002) Caveolin-1 expression enhances endothelial capillary tubule formation. J Biol Chem 277:10661–10668CrossRefPubMed
25.
Griffoni C, Spisni E, Santi S, Riccio M, Guarnieri T, Tomasi V (2000) Knockdown of caveolin-1 by antisense oligonucleotides impairs angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 276:756–761CrossRefPubMed
26.
Podar K, Shringarpure R, Tai YT, Simoncini M, Sattler M, Ishitsuka K, Richardson PG, Hideshima T, Chauhan D, Anderson KC (2004) Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib. Cancer Res 64:7500–7506CrossRefPubMed
Metadata
Title
Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery
Authors
Zhi-Bo Zhang
Lei Cai
Shu-Guo Zheng
Yan Xiong
Jia-Hong Dong
Publication date
01-09-2009
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 3/2009
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-008-9144-7

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