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Pathology & Oncology Research
Published in: Pathology & Oncology Research 3/2009

01-09-2009 | Original Paper

Gammaaminobutyric Acid A Receptor Alpha 3 Subunit is Overexpressed in Lung Cancer

Authors: Yan Liu, Fengjie Guo, Miao Dai, Di Wang, Yongqing Tong, Jian Huang, Jinyue Hu, Guancheng Li

Published in: Pathology & Oncology Research | Issue 3/2009

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Abstract

The identification of tumor-associated antigens, which are specifically expressed in cancer tissues, is very important for immunotherapy of lung cancer. We have combined the in silico screening and experimental verifying to identify genes that are differently expressed in cancers compared with their corresponding normal tissues. Using these methods, we have identified that GABRA3 gene was overexpressed in lung cancer and rarely expressed in other cancers. Furthermore, GABRA3 protein expression was significantly higher in the lower grade of lung cancer. It may compose functional GABA-gated channel with other subunits. This study demonstrated GABRA3 could be a potential biomarker for diagnosis of lung cancer, and GABAA receptors may play an important role in cancer differentiation.
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Metadata
Title
Gammaaminobutyric Acid A Receptor Alpha 3 Subunit is Overexpressed in Lung Cancer
Authors
Yan Liu
Fengjie Guo
Miao Dai
Di Wang
Yongqing Tong
Jian Huang
Jinyue Hu
Guancheng Li
Publication date
01-09-2009
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 3/2009
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-008-9128-7

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