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Published in: Environmental Health and Preventive Medicine 5/2014

01-09-2014 | Short Communication

Circulating leptin levels are associated with physical activity or physical fitness in Japanese

Authors: Nobuyuki Miyatake, Haruka Murakami, Ryoko Kawakami, Izumi Tabata, Motohiko Miyachi, The NEXIS Study Group

Published in: Environmental Health and Preventive Medicine | Issue 5/2014

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Abstract

Objective

The aim of this study was to evaluate the link between circulating leptin levels and physical activity and/or physical fitness in apparently healthy Japanese.

Methods

A total of 85 men and 111 women who were not taking any medication were enrolled in this cross-sectional study. Circulating leptin levels, physical activity measured by tri-axial accelerometers and peak oxygen uptake were evaluated. We also assessed anthropometric data, blood pressure, blood examinations and energy intake.

Results

Circulating leptin levels were 3.2 ± 2.3 ng/mL in men and 5.9 ± 3.8 ng/mL in women. Circulating leptin levels were significantly and positively correlated with body weight, body mass index, abdominal circumference, insulin and the homeostasis model assessment index, and significantly and negatively correlated with peak oxygen uptake in both sexes. Stepwise multiple regression showed that peak oxygen uptake in men and physical activity evaluated by \(\sum {\left[ {{\text{metabolic equivalents }} \times \rm h {\text{ per week}}({\text{METs}}\;\;h/w)} \right]}\) in women were determinant factors for circulating leptin levels after adjusting for confounding factors.
Literature
1.
go back to reference Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–32.PubMedCrossRef Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–32.PubMedCrossRef
2.
go back to reference Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Eng J Med. 1999;341:879–84.CrossRef Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Eng J Med. 1999;341:879–84.CrossRef
3.
go back to reference Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546–9.PubMedCrossRef Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546–9.PubMedCrossRef
4.
go back to reference Tang-Christensen M, Havel PJ, Jacobs RR, Larsen PJ, Cameron JL. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab. 1999;84:711–7.PubMed Tang-Christensen M, Havel PJ, Jacobs RR, Larsen PJ, Cameron JL. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab. 1999;84:711–7.PubMed
5.
go back to reference van Dielen FM, van’t Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab. 2002;87:1708–16.PubMedCrossRef van Dielen FM, van’t Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab. 2002;87:1708–16.PubMedCrossRef
6.
go back to reference Qasim A, Mehta NN, Tadesse MG, Wolfe ML, Rhodes T, Girman C, et al. Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol. 2008;52:231–6.PubMedCrossRefPubMedCentral Qasim A, Mehta NN, Tadesse MG, Wolfe ML, Rhodes T, Girman C, et al. Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol. 2008;52:231–6.PubMedCrossRefPubMedCentral
7.
go back to reference Morales A, Wasserfall C, Brusko T, Carter C, Shatz D, Silverstein J, et al. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care. 2004;27:2010–4.PubMedCrossRef Morales A, Wasserfall C, Brusko T, Carter C, Shatz D, Silverstein J, et al. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care. 2004;27:2010–4.PubMedCrossRef
8.
go back to reference Larsson H, Elmstahl S, Ahren B. Plasma leptin levels correlate to islet function independently of body fat in postmenopausal woman. Diabetes. 1996;45:1580–4.PubMedCrossRef Larsson H, Elmstahl S, Ahren B. Plasma leptin levels correlate to islet function independently of body fat in postmenopausal woman. Diabetes. 1996;45:1580–4.PubMedCrossRef
9.
go back to reference Miyatake N, Takahashi K, Wada J, Nishikawa H, Morishita A, Suzuki H, et al. Daily exercise lowers blood pressure and reduces visceral fat in overweight Japanese men. Diabetes Res Clin Pract. 2003;62:149–57.PubMedCrossRef Miyatake N, Takahashi K, Wada J, Nishikawa H, Morishita A, Suzuki H, et al. Daily exercise lowers blood pressure and reduces visceral fat in overweight Japanese men. Diabetes Res Clin Pract. 2003;62:149–57.PubMedCrossRef
10.
go back to reference Miyatake N, Nishikawa H, Morishita A, Kunitomi M, Wada J, Suzuki H, et al. Daily walking reduces visceral adipose tissue areas and improves insulin resistance in Japanese obese subjects. Diabetes Res Clin Pract. 2002;58:101–7.PubMedCrossRef Miyatake N, Nishikawa H, Morishita A, Kunitomi M, Wada J, Suzuki H, et al. Daily walking reduces visceral adipose tissue areas and improves insulin resistance in Japanese obese subjects. Diabetes Res Clin Pract. 2002;58:101–7.PubMedCrossRef
11.
go back to reference Yamanouchi K, Shinozaki T, Chikada K, Nishikawa T, Ito K, Shimizu S, et al. Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care. 1995;18:775–8.PubMedCrossRef Yamanouchi K, Shinozaki T, Chikada K, Nishikawa T, Ito K, Shimizu S, et al. Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care. 1995;18:775–8.PubMedCrossRef
12.
go back to reference Sawada SS, Lee IM, Muto T, Matsuzaki K, Blair SN. Cardiorespiratory fitness and the incidence of type 2 diabetes: prospective study of Japanese men. Diabetes Care. 2003;26:2918–22.PubMedCrossRef Sawada SS, Lee IM, Muto T, Matsuzaki K, Blair SN. Cardiorespiratory fitness and the incidence of type 2 diabetes: prospective study of Japanese men. Diabetes Care. 2003;26:2918–22.PubMedCrossRef
13.
go back to reference Sandvik L, Erikssen J, Thaulow E, Erikssen G, Mundal R, Rodahl K. Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men. N Engl J Med. 1993;328:533–7.PubMedCrossRef Sandvik L, Erikssen J, Thaulow E, Erikssen G, Mundal R, Rodahl K. Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men. N Engl J Med. 1993;328:533–7.PubMedCrossRef
14.
go back to reference Miyatake N, Takahashi K, Wada J, Nishikawa H, Morishita A, Suzuki H, et al. Changes in serum leptin concentrations in overweight Japanese men after exercise. Diabetes Obes Metab. 2004;6:332–7.PubMedCrossRef Miyatake N, Takahashi K, Wada J, Nishikawa H, Morishita A, Suzuki H, et al. Changes in serum leptin concentrations in overweight Japanese men after exercise. Diabetes Obes Metab. 2004;6:332–7.PubMedCrossRef
15.
go back to reference Martinez-Gomez D, Eisenmann JC, Gomez-Martinez S, Veses A, Romeo J, Veiga OL, AFINOS Study Group, et al. Associations physical activity and fitness with adipocytokines in adolescents: the AFINOS Study. Nutr Metab Cardiovasc Dis. 2012;22:252–9.PubMedCrossRef Martinez-Gomez D, Eisenmann JC, Gomez-Martinez S, Veses A, Romeo J, Veiga OL, AFINOS Study Group, et al. Associations physical activity and fitness with adipocytokines in adolescents: the AFINOS Study. Nutr Metab Cardiovasc Dis. 2012;22:252–9.PubMedCrossRef
16.
go back to reference Jimenez-Pavon D, Ortega FB, Artero EG, Labayen I, Vicente-Rodriguez G, Huybrechts I, HELENA Study Group, et al. Physical activity, fitness, and serum leptin concentrations in adolescents. J Pediatr. 2012;160:598–603.PubMedCrossRef Jimenez-Pavon D, Ortega FB, Artero EG, Labayen I, Vicente-Rodriguez G, Huybrechts I, HELENA Study Group, et al. Physical activity, fitness, and serum leptin concentrations in adolescents. J Pediatr. 2012;160:598–603.PubMedCrossRef
17.
go back to reference Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, et al. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013;8:e78350.PubMedCrossRefPubMedCentral Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, et al. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013;8:e78350.PubMedCrossRefPubMedCentral
18.
go back to reference Franks PW, Farooqi IS, Luan J, Wong MY, Halsall I, O’Rahilly S, et al. Does physical activity energy expenditure explain the between individual variation in plasma leptin concentrations after adjusting for differences in body composition? J Clin Endocrinol Metab. 2003;88:3258–63.PubMedCrossRef Franks PW, Farooqi IS, Luan J, Wong MY, Halsall I, O’Rahilly S, et al. Does physical activity energy expenditure explain the between individual variation in plasma leptin concentrations after adjusting for differences in body composition? J Clin Endocrinol Metab. 2003;88:3258–63.PubMedCrossRef
19.
go back to reference St-Pierre DH, Faraj M, Karelis AD, Conus F, Henry JF, St-Onge M, et al. Lifestyle behaviours and components of energy balance as independent predictors of ghrelin and adiponectin in young non-obese women. Diabetes Metab. 2006;32:131–9.PubMedCrossRef St-Pierre DH, Faraj M, Karelis AD, Conus F, Henry JF, St-Onge M, et al. Lifestyle behaviours and components of energy balance as independent predictors of ghrelin and adiponectin in young non-obese women. Diabetes Metab. 2006;32:131–9.PubMedCrossRef
20.
go back to reference Maimoun L, Simar D, Caillaud C, Coste O, Puech AM, Jaussent A, et al. Basal plasma leptin levels in healthy elderly males are related to physical fitness without impact on bone metabolism. J Sports Med Phys Fitness. 2011;51:160–8.PubMed Maimoun L, Simar D, Caillaud C, Coste O, Puech AM, Jaussent A, et al. Basal plasma leptin levels in healthy elderly males are related to physical fitness without impact on bone metabolism. J Sports Med Phys Fitness. 2011;51:160–8.PubMed
21.
go back to reference Miller GD, Frost R, Olive J. Relation of plasma leptin concentrations to sex, body fat, dietary intake, and peak oxygen uptake in young adult women and men. Nutrition. 2001;17:105–11.PubMedCrossRef Miller GD, Frost R, Olive J. Relation of plasma leptin concentrations to sex, body fat, dietary intake, and peak oxygen uptake in young adult women and men. Nutrition. 2001;17:105–11.PubMedCrossRef
22.
go back to reference Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.PubMedCrossRef Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.PubMedCrossRef
23.
go back to reference Miyatake N, Numata T, Murakami H, Kawakami R, Sanada K, Tabata I, et al.: Circulating adiponectin levels are associated with peak oxygen uptake in Japanese. Environ Health Prev Med. 2014;19:279–85. Miyatake N, Numata T, Murakami H, Kawakami R, Sanada K, Tabata I, et al.: Circulating adiponectin levels are associated with peak oxygen uptake in Japanese. Environ Health Prev Med. 2014;19:279–85.
24.
go back to reference Koutsari C, Karpe F, Humphereys SM, Frayn KN, Hardman AE. Plasma leptin is influenced by diet composition and exercise. Int J Obes Relat Metab Disord. 2003;27:901–6.PubMedCrossRef Koutsari C, Karpe F, Humphereys SM, Frayn KN, Hardman AE. Plasma leptin is influenced by diet composition and exercise. Int J Obes Relat Metab Disord. 2003;27:901–6.PubMedCrossRef
25.
go back to reference Pelleymouter MA, Cullen MJ, Barker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540–3.CrossRef Pelleymouter MA, Cullen MJ, Barker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540–3.CrossRef
26.
go back to reference Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, et al. The hypothalamic arcuate nucleus: a key site for mediating leptin’s effects on glucose homeostasis and locomotor activity. Cell Metab. 2005;1:63–72.PubMedCrossRef Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, et al. The hypothalamic arcuate nucleus: a key site for mediating leptin’s effects on glucose homeostasis and locomotor activity. Cell Metab. 2005;1:63–72.PubMedCrossRef
27.
go back to reference Murakami H, Iemitsu M, Fuku N, Sanada K, Gando Y, Kawakami R, et al. The Q223R polymorphism in the leptin receptor associates with objectively measured light physical activity in free-living Japanese. Physiol Behav. 2014;129:199–204.PubMedCrossRef Murakami H, Iemitsu M, Fuku N, Sanada K, Gando Y, Kawakami R, et al. The Q223R polymorphism in the leptin receptor associates with objectively measured light physical activity in free-living Japanese. Physiol Behav. 2014;129:199–204.PubMedCrossRef
28.
go back to reference Moro C, Pillard F, de Glisezinski I, Crampes F, Thalamas C, Harant I, et al. Sex differences in lipolysis-regulating mechanisms in overweight subjects: effect of exercise intensity. Obesity (Silver Spring). 2007;15:2245–55.CrossRef Moro C, Pillard F, de Glisezinski I, Crampes F, Thalamas C, Harant I, et al. Sex differences in lipolysis-regulating mechanisms in overweight subjects: effect of exercise intensity. Obesity (Silver Spring). 2007;15:2245–55.CrossRef
29.
go back to reference Casabiell X, Pineiro V, Peino R, Lage M, Camina J, Gallego R, et al. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab. 1998;83:2149–55.PubMed Casabiell X, Pineiro V, Peino R, Lage M, Camina J, Gallego R, et al. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab. 1998;83:2149–55.PubMed
Metadata
Title
Circulating leptin levels are associated with physical activity or physical fitness in Japanese
Authors
Nobuyuki Miyatake
Haruka Murakami
Ryoko Kawakami
Izumi Tabata
Motohiko Miyachi
The NEXIS Study Group
Publication date
01-09-2014
Publisher
Springer Japan
Published in
Environmental Health and Preventive Medicine / Issue 5/2014
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1007/s12199-014-0398-2

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