Published in:
01-03-2019 | Lymphoma | Images in Hematology
Is clinicopathological distinction of mucosa-associated lymphoid tissue lymphoma from Waldenström macroglobulinemia essential in MYD88 L265P mutation-positive cases?
Authors:
Keisuke Kidoguchi, Kensuke Kojima, Ritsuko Seki, Koji Nagafuji, Koichi Ohshima, Shinya Kimura
Published in:
International Journal of Hematology
|
Issue 3/2019
Login to get access
Excerpt
A 54-year-old man underwent liver segmentectomy for a solitary MALT lymphoma (4 cm in the longest diameter) found during his annual medical checkup (Fig.
1a, b). He was seronegative for hepatitis B surface antigen and antibodies against hepatitis C. Four years later, he developed Waldenström macroglobulinemia in the absence of tumorous lesions (Fig.
1c, d). MYD88 L265P mutation was detected in formalin-fixed and paraffin-embedded liver tumor tissue and bone marrow biopsy specimen. The clinicopathological transition indicates that MYD88 L265P mutation, a diagnostic biomarker for WM/LPL, does not always differentiate WM/LPL from other B-cell disorders. Whether patients with this mutation benefit from BTK inhibitor treatment irrespective of histopathological diagnosis is a clinically important question. …
