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International Journal of Hematology
Published in: International Journal of Hematology 5/2015

01-11-2015 | Progress in Hematology

Multistep tumorigenesis in peripheral T cell lymphoma

Author: Mamiko Sakata-Yanagimoto

Published in: International Journal of Hematology | Issue 5/2015

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Abstract

Peripheral T cell lymphomas (PTCL) are classified as mature T cell neoplasms. However, several new findings support the notion that premalignant cells arise in the immature stage of hematopoietic differentiation, and subsequently evolve into full-blown T-lineage tumor cells. Acquisition of (Ten-Eleven Translocation 2) TET2 mutations may be an important event for the establishment of premalignant cells. In PTCL harboring features of follicular helper T cells, tumor-specific G17V RHOA mutations co-occur with premalignant TET2 mutations. The G17V (ras homolog family member A) RHOA mutations may play important roles in clonal evolution of premalignant cells into tumor cells. Indeed, multistep tumorigenesis is thought to be essential for pathogenesis of PTCL.
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Metadata
Title
Multistep tumorigenesis in peripheral T cell lymphoma
Author
Mamiko Sakata-Yanagimoto
Publication date
01-11-2015
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 5/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-015-1738-8

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