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01-05-2015 | Case Report

A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission

Authors: Minoru Kojima, Naoya Nakamura, Miharu Yabe, Mami Tokunaka, Yara Yukie Kikuti, Tomoki Kikuchi, Hiromichi Murayama, Makiko Moriuchi, Kosuke Tsuboi, Yoshiaki Ogawa, Kiyoshi Ando

Published in: International Journal of Hematology | Issue 5/2015

Abstract

We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct. The patient received the R-Hyper CVAD/R-MA regimen; however, leukoencephalopathy subsequently developed due to the effect of cytarabine, and the regimen was changed to R-IVAM. The patient achieved complete remission and received high-dose chemotherapy following autologous stem cell transplantation. He maintained the complete remission for 72 months after transplantation. Given this outcome, we suggest that clonally distinct relapse of HIV-negative BL may exhibit a good prognosis.

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Title: A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission
Authors: Minoru Kojima
Naoya Nakamura
Miharu Yabe
Mami Tokunaka
Yara Yukie Kikuti
Tomoki Kikuchi
Hiromichi Murayama
Makiko Moriuchi
Kosuke Tsuboi
Yoshiaki Ogawa
Kiyoshi Ando
Publication date: 01-05-2015
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 5/2015
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-014-1729-1

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