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01-04-2014 | Original Article

Thromboelastometry profile in children with beta-thalassemia

Authors: Ayşe B. Turhan, Özcan Bör, O. Meltem Akay, Necat A. Akgün

Published in: International Journal of Hematology | Issue 4/2014

Abstract

Beta (β)-thalassemia is characterized by a hypercoagulable state and an increased risk of thrombosis, which can result in significant morbidity and mortality. The coagulation pattern and determinants of thrombosis in patients with β-thalassemia remain largely unknown. The aim of this study was to evaluate the whole blood thromboelastometry (TEM) profile of β-thalassemic children by ROTEM^®. ROTEM^® assays (INTEM, EXTEM) and traditional coagulation parameters (platelet count, prothrombin time, activated partial thromboplastin time, and fibrinogen) were performed on blood samples from 17 subjects with β-thalassemia and 19 non-thalassemic controls. Maximum clot firmness (MCF) was significantly higher in subjects with β-thalassemia than in controls on EXTEM and INTEM analysis (p < 0.001 and p < 0.001, respectively). Of the patients with β-thalassemia, MCF was higher and clot formation time was shorter in splenectomized subjects than in non-splenectomized subjects on EXTEM and INTEM (p = 0.026, p = 0.002, p < 0.001, p < 0.001, respectively). TEM profiles in β-thalassemic children were more hypercoagulable compared with controls. Larger prospective studies are needed to evaluate the relevance of the association between ROTEM^® profile and thromboembolic events in patients with β-thalassemia.

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Title: Thromboelastometry profile in children with beta-thalassemia
Authors: Ayşe B. Turhan
Özcan Bör
O. Meltem Akay
Necat A. Akgün
Publication date: 01-04-2014
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 4/2014
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-014-1546-6

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