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International Journal of Hematology
Published in: International Journal of Hematology 2/2010

01-03-2010 | Rapid Communication

mRNA expression of the XAGE-1 gene in human acute leukemia

Authors: Yuqiang Ji, Wanggang Zhang, Jin Wang, Liufang Gu

Published in: International Journal of Hematology | Issue 2/2010

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Abstract

XAGE-1 is a cancer-testis antigen, which was demonstrated to be expressed at a significant frequency and to be immunogenic in some solid tumors. We analyzed the expression of 4 XAGE-1 transcript variant gene in human acute leukemias by reverse-transcription polymerase chain reaction. Among the 114 acute leukemias, 14/63 (22.22%) of the acute myeloid leukemia samples were positive for XAGE-1b genes. XAGE-1b mRNA expression was detected in 10/51 (19.61%) of the acute lymphocyte leukemia samples. However, we did not find any important correlation between XAGE-1b mRNA expression and clinical characteristics, such as sex, leukemia type, response to therapy and the percentage of blast in the first diagnosed bone marrow. We concluded that the XAGE-1b gene was expressed at the mRNA level in a proportion of human acute leukemia.
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Metadata
Title
mRNA expression of the XAGE-1 gene in human acute leukemia
Authors
Yuqiang Ji
Wanggang Zhang
Jin Wang
Liufang Gu
Publication date
01-03-2010
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 2/2010
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-010-0527-7

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