Published in:
01-07-2008 | Letter to the Editor
All-trans-retinoic acid as a possible cause of acute pancreatitis even in the absence of hypertriglyceridemia
Authors:
Takumi Hoshino, Nahoko Hatsumi, Satoru Takada, Tohru Sakura, Shuichi Miyawaki
Published in:
International Journal of Hematology
|
Issue 1/2008
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Excerpt
The standard therapy for patients affected by acute promyelocytic leukemia (APL) is the administration of all-trans-retinoic acid (ATRA). ATRA therapy is usually well-tolerated, but it also has the potential to induce toxicity. The most severe side effect of ATRA is retinoic acid syndrome; the next is acute pancreatitis, which is a rare but serious adverse event mostly due to hypertriglyceridemia. We herein report a patient who developed ATRA-induced acute pancreatitis without hypertriglyceridemia. …