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Published in: International Journal of Hematology 1/2008

01-07-2008 | Letter to the Editor

All-trans-retinoic acid as a possible cause of acute pancreatitis even in the absence of hypertriglyceridemia

Authors: Takumi Hoshino, Nahoko Hatsumi, Satoru Takada, Tohru Sakura, Shuichi Miyawaki

Published in: International Journal of Hematology | Issue 1/2008

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Excerpt

The standard therapy for patients affected by acute promyelocytic leukemia (APL) is the administration of all-trans-retinoic acid (ATRA). ATRA therapy is usually well-tolerated, but it also has the potential to induce toxicity. The most severe side effect of ATRA is retinoic acid syndrome; the next is acute pancreatitis, which is a rare but serious adverse event mostly due to hypertriglyceridemia. We herein report a patient who developed ATRA-induced acute pancreatitis without hypertriglyceridemia. …
Literature
1.
go back to reference Abou CL, Ghosn M, Ghayad E, Honein K. A case of pancreatitis associated with all-trans-retinoic acid therapy in acute promyelocytic leukemia. Haematol J. 2001;2:406–7.CrossRef Abou CL, Ghosn M, Ghayad E, Honein K. A case of pancreatitis associated with all-trans-retinoic acid therapy in acute promyelocytic leukemia. Haematol J. 2001;2:406–7.CrossRef
3.
go back to reference Yutsudo Y, Imoto S, Ozuru R, et al. Acute pancreatitis after all-trans retinoic acid therapy. Ann Hematol. 1997;74:295–6.CrossRefPubMed Yutsudo Y, Imoto S, Ozuru R, et al. Acute pancreatitis after all-trans retinoic acid therapy. Ann Hematol. 1997;74:295–6.CrossRefPubMed
4.
go back to reference Teng HW, Bai LY, Chao TC, Wang WS, Chen PM. Acute pancreatitis during all-trans-retinoic acid treatment for acute promyelocytic leukemia in a patient without overt hypertriglyceridemia. Jpn J Clin Oncol. 2005;35(2):94–6.CrossRefPubMed Teng HW, Bai LY, Chao TC, Wang WS, Chen PM. Acute pancreatitis during all-trans-retinoic acid treatment for acute promyelocytic leukemia in a patient without overt hypertriglyceridemia. Jpn J Clin Oncol. 2005;35(2):94–6.CrossRefPubMed
5.
go back to reference Hatake K, Uwai M, Ohtsuko T, et al. Rare but important adverse effects of all-trans retinoic acid in acute promyelocytic leukemia and their management. Int J Hematol. 1997;66:13–9.CrossRefPubMed Hatake K, Uwai M, Ohtsuko T, et al. Rare but important adverse effects of all-trans retinoic acid in acute promyelocytic leukemia and their management. Int J Hematol. 1997;66:13–9.CrossRefPubMed
6.
go back to reference Makhija R, Kingsnorth AN. Cytokine storm in acute pancreatitis. J Hepatobiliary Pancreat Surg. 2002;9:401–10.CrossRefPubMed Makhija R, Kingsnorth AN. Cytokine storm in acute pancreatitis. J Hepatobiliary Pancreat Surg. 2002;9:401–10.CrossRefPubMed
7.
go back to reference Hsu HC, Tsai WH, Chen PG, Hsu ML, Ho CK, Wang SY. In vitro effect of granulocyte-colony stimulating factor and all-trans retinoic acid on the expression of inflammatory cytokines and adhesion molecules in acute promyelocytic leukemic cells. Eur J Haematol. 1999;63:11–8.CrossRefPubMed Hsu HC, Tsai WH, Chen PG, Hsu ML, Ho CK, Wang SY. In vitro effect of granulocyte-colony stimulating factor and all-trans retinoic acid on the expression of inflammatory cytokines and adhesion molecules in acute promyelocytic leukemic cells. Eur J Haematol. 1999;63:11–8.CrossRefPubMed
8.
go back to reference McCarroll JA, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte MV. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. Gut. 2006;55(1):79–89.CrossRefPubMedPubMedCentral McCarroll JA, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte MV. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. Gut. 2006;55(1):79–89.CrossRefPubMedPubMedCentral
Metadata
Title
All-trans-retinoic acid as a possible cause of acute pancreatitis even in the absence of hypertriglyceridemia
Authors
Takumi Hoshino
Nahoko Hatsumi
Satoru Takada
Tohru Sakura
Shuichi Miyawaki
Publication date
01-07-2008
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 1/2008
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-008-0116-1

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