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Current Reviews in Musculoskeletal Medicine

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01-06-2020 | Stem Cells in Orthopaedic Surgery (J Dragoo and K Jones, Section Editors)

Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations

Authors: Kyle N. Kunze, Robert A. Burnett, Joshua Wright-Chisem, Rachel M. Frank, Jorge Chahla

Published in: Current Reviews in Musculoskeletal Medicine | Issue 3/2020

Abstract

Purpose of Review

The use of human adipose-derived mesenchymal stem cells (ADSCs) has gained attention due to its potential to expedite healing and the ease of harvesting; however, clinical evidence is limited, and questions concerning optimal method of delivery and long-term outcomes remain unanswered.

Recent Findings

Administration of ADSCs in animal models has been reported to aid in improved healing benefits with enhanced repair biomechanics, superior gross histological appearance of injury sites, and higher concentrations of growth factors associated with healing compared to controls. Recently, an increasing body of research has sought to examine the effects of ADSCs in humans.

Summary

Several available processing techniques and formulations for ADSCs exist with evidence to suggest benefits with the use of ADSCs, but the superiority of any one method is not clear. Evidence from the most recent clinical studies available demonstrates promising outcomes following treatment of select musculoskeletal pathologies with ADSCs despite reporting variability among ADSCs harvesting and processing; these include (1) healing benefits and pain improvement for rotator cuff and Achilles tendinopathies, (2) improvements in pain and function in those with knee and hip osteoarthritis, and (3) improved cartilage regeneration for osteochondral focal defects of the knee and talus. The limitation to most of this literature is the use of other therapeutic biologics in combination with ADSCs. Additionally, many studies lack control groups, making establishment of causation inappropriate. It is imperative to perform higher-quality studies using consistent, predictable control populations and to standardize formulations of ADSCs in these trials.

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Title: Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations
Authors: Kyle N. Kunze
Robert A. Burnett
Joshua Wright-Chisem
Rachel M. Frank
Jorge Chahla
Publication date: 01-06-2020
Publisher: Springer US
Published in: Current Reviews in Musculoskeletal Medicine / Issue 3/2020
Electronic ISSN: 1935-9748
DOI: https://doi.org/10.1007/s12178-020-09624-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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