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Journal of Ocular Biology, Diseases, and Informatics

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Open Access 01-12-2008 | Review

Mechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation

Author: Junko Hori

Published in: Journal of Ocular Biology, Diseases, and Informatics | Issue 2-4/2008

Abstract

The eye, like the brain and reproductive organs, possesses inherent immune privilege, and inflammation is self-regulated so as to preserve the organ functions. Studies over the past 30 years have provided insights of the multiple mechanisms of immune privilege. At present, three major lines of thought prevail regarding the molecular mechanisms of immune privilege in the eye: there are (1) anatomical, cellular, and molecular barriers in the eye; (2) eye-derived immunological tolerance, the so-called anterior chamber-associated immune deviation; and (3) immune suppressive intraocular microenvironment. In this review, the mechanisms of immune privilege that have been learned from ocular inflammation animal models, especially corneal transplantation, are described. Roles of new B7 family molecules on local immune regulation within the cornea are also introduced.

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Title: Mechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation
Author: Junko Hori
Publication date: 01-12-2008
Publisher: Humana Press Inc
Published in: Journal of Ocular Biology, Diseases, and Informatics / Issue 2-4/2008
Electronic ISSN: 1936-8445
DOI: https://doi.org/10.1007/s12177-008-9010-6

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Mechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation

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