Skip to main content
Top
Published in: Annals of Behavioral Medicine 4/2015

01-08-2015 | Original Article

Exercise as Treatment for Anxiety: Systematic Review and Analysis

Authors: Gregory L. Stonerock, Ph.D., Benson M. Hoffman, Ph.D., Patrick J. Smith, Ph.D., James A. Blumenthal, Ph.D.

Published in: Annals of Behavioral Medicine | Issue 4/2015

Login to get access

Abstract

Background

Exercise has been shown to reduce symptoms of anxiety, but few studies have studied exercise in individuals preselected because of their high anxiety.

Purpose

The objective of this study is to review and critically evaluate studies of exercise training in adults with either high levels of anxiety or an anxiety disorder.

Methods

We conducted a systematic review of randomized clinical trials (RCTs) in which anxious adults were randomized to an exercise or nonexercise control condition. Data were extracted concerning anxiety outcomes and study design. Existing meta-analyses were also reviewed.

Results

Evidence from 12 RCTs suggested benefits of exercise, for select groups, similar to established treatments and greater than placebo. However, most studies had significant methodological limitations, including small sample sizes, concurrent therapies, and inadequate assessment of adherence and fitness levels.

Conclusions

Exercise may be a useful treatment for anxiety, but lack of data from rigorous, methodologically sound RCTs precludes any definitive conclusions about its effectiveness.
Literature
1.
go back to reference Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013.
2.
go back to reference Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen H-U. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res. 2012; 21: 169-184.PubMedCentralPubMed Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen H-U. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res. 2012; 21: 169-184.PubMedCentralPubMed
3.
go back to reference Haller H, Cramer H, Lauche R, Gass F, Dobos G. The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review. BMC Psychiatry. 2014; 14: 128.PubMedCentralPubMed Haller H, Cramer H, Lauche R, Gass F, Dobos G. The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review. BMC Psychiatry. 2014; 14: 128.PubMedCentralPubMed
4.
go back to reference Stein MB, Roy-Byrne PP, Craske MG, et al. Functional impact and health utility of anxiety disorders in primary care outpatients. Med Care. 2005; 43: 1164-1170.PubMed Stein MB, Roy-Byrne PP, Craske MG, et al. Functional impact and health utility of anxiety disorders in primary care outpatients. Med Care. 2005; 43: 1164-1170.PubMed
5.
go back to reference Tolmunen T, Lehto SM, Julkunen J, Hintikka J, Kauhanen J. Trait anxiety and somatic concerns associate with increased mortality risk: a 23-year follow-up in aging men. Ann Epidemiol. 2014; 24: 463-468.PubMed Tolmunen T, Lehto SM, Julkunen J, Hintikka J, Kauhanen J. Trait anxiety and somatic concerns associate with increased mortality risk: a 23-year follow-up in aging men. Ann Epidemiol. 2014; 24: 463-468.PubMed
6.
go back to reference Roest AM, Martens EJ, de Jonge P, Denollet J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol. 2010; 56: 38-46.PubMed Roest AM, Martens EJ, de Jonge P, Denollet J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol. 2010; 56: 38-46.PubMed
7.
go back to reference Janszky I, Ahnve S, Lundberg I, Hemmingsson T. Early-onset depression, anxiety, and risk of subsequent coronary heart disease: 37-year follow-up of 49,321 young Swedish men. J Am Coll Cardiol. 2010; 56: 31-37.PubMed Janszky I, Ahnve S, Lundberg I, Hemmingsson T. Early-onset depression, anxiety, and risk of subsequent coronary heart disease: 37-year follow-up of 49,321 young Swedish men. J Am Coll Cardiol. 2010; 56: 31-37.PubMed
8.
go back to reference Roest AM, Martens EJ, Denollet J, de Jonge P. Prognostic association of anxiety post myocardial infarction with mortality and new cardiac events: a meta-analysis. Psychosom Med. 2010; 72: 563-569.PubMed Roest AM, Martens EJ, Denollet J, de Jonge P. Prognostic association of anxiety post myocardial infarction with mortality and new cardiac events: a meta-analysis. Psychosom Med. 2010; 72: 563-569.PubMed
9.
go back to reference Frasure-Smith N, Lespérance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008; 65: 62-71.PubMed Frasure-Smith N, Lespérance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008; 65: 62-71.PubMed
10.
go back to reference Frasure-Smith N. In-hospital symptoms of psychological stress as predictors of long-term outcome after acute myocardial infarction in men. Am J Cardiol. 1991; 67: 121-127.PubMed Frasure-Smith N. In-hospital symptoms of psychological stress as predictors of long-term outcome after acute myocardial infarction in men. Am J Cardiol. 1991; 67: 121-127.PubMed
11.
go back to reference Tully PJ, Baker RA, Knight JL. Anxiety and depression as risk factors for mortality after coronary artery bypass surgery. J Psychosom Res. 2008; 64: 285-290.PubMed Tully PJ, Baker RA, Knight JL. Anxiety and depression as risk factors for mortality after coronary artery bypass surgery. J Psychosom Res. 2008; 64: 285-290.PubMed
12.
go back to reference Tully P, Baker R, Turnbull D, Winefield H. The role of depression and anxiety symptoms in hospital readmissions after cardiac surgery. J Behav Med. 2008; 31: 281-290.PubMed Tully P, Baker R, Turnbull D, Winefield H. The role of depression and anxiety symptoms in hospital readmissions after cardiac surgery. J Behav Med. 2008; 31: 281-290.PubMed
13.
go back to reference Szekely A, Balog P, Benko E, et al. Anxiety predicts mortality and morbidity after coronary artery and valve surgery—a 4-year follow-up study. Psychosom Med. 2007; 69: 625-631.PubMed Szekely A, Balog P, Benko E, et al. Anxiety predicts mortality and morbidity after coronary artery and valve surgery—a 4-year follow-up study. Psychosom Med. 2007; 69: 625-631.PubMed
14.
go back to reference Moser DK, McKinley S, Riegel B, et al. Relationship of persistent symptoms of anxiety to morbidity and mortality outcomes in patients with coronary heart disease. Psychosom Med. 2011; 73: 803-809.PubMed Moser DK, McKinley S, Riegel B, et al. Relationship of persistent symptoms of anxiety to morbidity and mortality outcomes in patients with coronary heart disease. Psychosom Med. 2011; 73: 803-809.PubMed
15.
go back to reference Watkins LL, Koch GG, Sherwood A, et al. Association of anxiety and depression with all‐cause mortality in individuals with coronary heart disease. J Am Heart Assoc. 2013; 2. Watkins LL, Koch GG, Sherwood A, et al. Association of anxiety and depression with all‐cause mortality in individuals with coronary heart disease. J Am Heart Assoc. 2013; 2.
16.
go back to reference Rothenbacher D, Hahmann H, Wusten B, Koenig W, Brenner H. Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Eur J Cardiovasc Prev Rehabil. 2007; 14: 547-554.PubMed Rothenbacher D, Hahmann H, Wusten B, Koenig W, Brenner H. Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Eur J Cardiovasc Prev Rehabil. 2007; 14: 547-554.PubMed
17.
go back to reference Strik JJ, Denollet J, Lousberg R, Honig A. Comparing symptoms of depression and anxiety as predictors of cardiac events and increased health care consumption after myocardial infarction. J Am Coll Cardiol. 2003; 42: 1801-1807.PubMed Strik JJ, Denollet J, Lousberg R, Honig A. Comparing symptoms of depression and anxiety as predictors of cardiac events and increased health care consumption after myocardial infarction. J Am Coll Cardiol. 2003; 42: 1801-1807.PubMed
18.
go back to reference Shibeshi WA, Young-Xu Y, Blatt CM. Anxiety worsens prognosis in patients with coronary artery disease. J Am Coll Cardiol. 2007; 49: 2021-2027.PubMed Shibeshi WA, Young-Xu Y, Blatt CM. Anxiety worsens prognosis in patients with coronary artery disease. J Am Coll Cardiol. 2007; 49: 2021-2027.PubMed
19.
go back to reference Markovitz JH, Matthews KA, Kannel WB, Cobb JL, D’Agostino RB. Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension? J Am Med Assoc. 1993; 270: 2439-2443. Markovitz JH, Matthews KA, Kannel WB, Cobb JL, D’Agostino RB. Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension? J Am Med Assoc. 1993; 270: 2439-2443.
20.
go back to reference Kawachi I, Sparrow D, Vokonas PS, Weiss ST. Symptoms of anxiety and risk of coronary heart disease. The Normative Aging Study. Circulation. 1994; 90: 2225-2229.PubMed Kawachi I, Sparrow D, Vokonas PS, Weiss ST. Symptoms of anxiety and risk of coronary heart disease. The Normative Aging Study. Circulation. 1994; 90: 2225-2229.PubMed
21.
go back to reference McCarron P, Gunnell D, Harrison GL, Okasha M, Davey Smith G. Temperament in young adulthood and later mortality: prospective observational study. J Epidemiol Community Health. 2003; 57: 888-892.PubMedCentralPubMed McCarron P, Gunnell D, Harrison GL, Okasha M, Davey Smith G. Temperament in young adulthood and later mortality: prospective observational study. J Epidemiol Community Health. 2003; 57: 888-892.PubMedCentralPubMed
22.
go back to reference Bonnet F, Irving K, Terra J-L, et al. Anxiety and depression are associated with unhealthy lifestyle in patients at risk of cardiovascular disease. Atherosclerosis. 2005; 178: 339-344.PubMed Bonnet F, Irving K, Terra J-L, et al. Anxiety and depression are associated with unhealthy lifestyle in patients at risk of cardiovascular disease. Atherosclerosis. 2005; 178: 339-344.PubMed
23.
go back to reference Jonas BS, Franks P, Ingram DD. Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the national health and nutrition examination survey I epidemiologic follow-up study. Arch Fam Med. 1997; 6: 43-49.PubMed Jonas BS, Franks P, Ingram DD. Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the national health and nutrition examination survey I epidemiologic follow-up study. Arch Fam Med. 1997; 6: 43-49.PubMed
24.
go back to reference Barlow DH. Clinical handbook of psychological disorders: A step-by-step treatment manual. 5th ed. New York, NY: The Guilford Press; 2014. Barlow DH. Clinical handbook of psychological disorders: A step-by-step treatment manual. 5th ed. New York, NY: The Guilford Press; 2014.
25.
go back to reference Barlow DH, Gorman JM, Shear M, Woods SW. Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: a randomized controlled trial. J Am Med Assoc. 2000; 283: 2529-2536. Barlow DH, Gorman JM, Shear M, Woods SW. Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: a randomized controlled trial. J Am Med Assoc. 2000; 283: 2529-2536.
26.
go back to reference Butler AC, Chapman JE, Forman EM, Beck AT. The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clin Psychol Rev. 2006; 26: 17-31.PubMed Butler AC, Chapman JE, Forman EM, Beck AT. The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clin Psychol Rev. 2006; 26: 17-31.PubMed
27.
go back to reference Kapczinski F, Lima MS, Souza JS, Schmitt R. Antidepressants for generalized anxiety disorder. Cochrane Database Syst Rev. 2003. Kapczinski F, Lima MS, Souza JS, Schmitt R. Antidepressants for generalized anxiety disorder. Cochrane Database Syst Rev. 2003.
28.
go back to reference Stahl SM, Gergel I, Li D. Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2003; 64: 1322-1327.PubMed Stahl SM, Gergel I, Li D. Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2003; 64: 1322-1327.PubMed
29.
go back to reference Davidson JRT, Bose A, Korotzer A, Zheng H. Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo controlled, flexible-dose study. Depression Anxiety. 2004; 19: 234-240.PubMed Davidson JRT, Bose A, Korotzer A, Zheng H. Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo controlled, flexible-dose study. Depression Anxiety. 2004; 19: 234-240.PubMed
30.
go back to reference Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2005; 19: 567-596.PubMed Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2005; 19: 567-596.PubMed
31.
go back to reference Pampallona S, Bollini P, Tibaldi G, Kupelnick B, Munizza C. Patient adherence in the treatment of depression. Br J Psychiatry. 2002; 180: 104-109.PubMed Pampallona S, Bollini P, Tibaldi G, Kupelnick B, Munizza C. Patient adherence in the treatment of depression. Br J Psychiatry. 2002; 180: 104-109.PubMed
32.
go back to reference Gunter RW, Whittal ML. Dissemination of cognitive-behavioral treatments for anxiety disorders: overcoming barriers and improving patient access. Clin Psychol Rev. 2010; 30: 194-202.PubMed Gunter RW, Whittal ML. Dissemination of cognitive-behavioral treatments for anxiety disorders: overcoming barriers and improving patient access. Clin Psychol Rev. 2010; 30: 194-202.PubMed
33.
go back to reference Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985; 100: 126-131.PubMedCentralPubMed Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985; 100: 126-131.PubMedCentralPubMed
34.
go back to reference Goodwin RD. Association between physical activity and mental disorders among adults in the United States. Prev Med. 2003; 36: 698-703.PubMed Goodwin RD. Association between physical activity and mental disorders among adults in the United States. Prev Med. 2003; 36: 698-703.PubMed
35.
go back to reference De Moor MHM, Beem AL, Stubbe JH, Boomsma DI, De Geus EJC. Regular exercise, anxiety, depression and personality: a population-based study. Prev Med. 2006; 42: 273-279.PubMed De Moor MHM, Beem AL, Stubbe JH, Boomsma DI, De Geus EJC. Regular exercise, anxiety, depression and personality: a population-based study. Prev Med. 2006; 42: 273-279.PubMed
37.
go back to reference Esquivel G, Diaz-Galvis J, Schruers K, et al. Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder. J Affect Disord. 2008; 107: 217-220.PubMed Esquivel G, Diaz-Galvis J, Schruers K, et al. Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder. J Affect Disord. 2008; 107: 217-220.PubMed
38.
go back to reference Yeung RR. The acute effects of exercise on mood state. J Psychosom Res. 1996; 40: 123-141.PubMed Yeung RR. The acute effects of exercise on mood state. J Psychosom Res. 1996; 40: 123-141.PubMed
39.
go back to reference Berger BG, Owen DR. Relation of low and moderate intensity exercise with acute mood change in college joggers. Percept Mot Skills. 1998; 87: 611-621.PubMed Berger BG, Owen DR. Relation of low and moderate intensity exercise with acute mood change in college joggers. Percept Mot Skills. 1998; 87: 611-621.PubMed
40.
go back to reference King AC, Taylor CB, Haskell WL. Effects of differing intensities and formats of 12 months of exercise training on psychological outcomes in older adults. Health Psychol. 1993; 12: 292-300.PubMed King AC, Taylor CB, Haskell WL. Effects of differing intensities and formats of 12 months of exercise training on psychological outcomes in older adults. Health Psychol. 1993; 12: 292-300.PubMed
41.
go back to reference Tsai J-C, Wang W-H, Chan P, et al. The beneficial effects of Tai Chi Chuan on blood pressure and lipid profile and anxiety status in a randomized controlled trial. J Altern Complement Med. 2003; 9: 747-754.PubMed Tsai J-C, Wang W-H, Chan P, et al. The beneficial effects of Tai Chi Chuan on blood pressure and lipid profile and anxiety status in a randomized controlled trial. J Altern Complement Med. 2003; 9: 747-754.PubMed
42.
go back to reference Stavrakaki C, Vargo B. The relationship of anxiety and depression: a review of the literature. Br J Psychiatry. 1986; 149: 7-16.PubMed Stavrakaki C, Vargo B. The relationship of anxiety and depression: a review of the literature. Br J Psychiatry. 1986; 149: 7-16.PubMed
43.
go back to reference Zung WW, Magruder-Habib K, Velez R, Alling W. The comorbidity of anxiety and depression in general medical patients: a longitudinal study. J Clin Psychiatry. 1990; 51: 77-80.PubMed Zung WW, Magruder-Habib K, Velez R, Alling W. The comorbidity of anxiety and depression in general medical patients: a longitudinal study. J Clin Psychiatry. 1990; 51: 77-80.PubMed
44.
go back to reference Cooney GM, Dwan K, Greig CA, et al. Exercise for depression. Cochrane Database Syst Rev. 2013; 9: Cd004366.PubMed Cooney GM, Dwan K, Greig CA, et al. Exercise for depression. Cochrane Database Syst Rev. 2013; 9: Cd004366.PubMed
45.
go back to reference Mead GE, Morley W, Campbell P, et al. Exercise for depression. Cochrane Database Syst Rev. 2009:Cd004366. Mead GE, Morley W, Campbell P, et al. Exercise for depression. Cochrane Database Syst Rev. 2009:Cd004366.
46.
go back to reference Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ. 2001; 322: 763.PubMedCentralPubMed Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ. 2001; 322: 763.PubMedCentralPubMed
47.
go back to reference Herring MP, O’Connor PJ, Dishman RK. The effect of exercise training on anxiety symptoms among patients: a systematic review. Arch Intern Med. 2010; 170: 321-331.PubMed Herring MP, O’Connor PJ, Dishman RK. The effect of exercise training on anxiety symptoms among patients: a systematic review. Arch Intern Med. 2010; 170: 321-331.PubMed
48.
go back to reference Conn VS. Anxiety outcomes after physical activity interventions: meta-analysis findings. Nurs Res. 2010; 59. Conn VS. Anxiety outcomes after physical activity interventions: meta-analysis findings. Nurs Res. 2010; 59.
49.
go back to reference Wipfli BM, Rethorst CD, Landers DM. The anxiolytic effects of exercise: a meta-analysis of randomized trials and dose-response analysis. J Sport Exerc Psychol. 2008; 30: 392-410.PubMed Wipfli BM, Rethorst CD, Landers DM. The anxiolytic effects of exercise: a meta-analysis of randomized trials and dose-response analysis. J Sport Exerc Psychol. 2008; 30: 392-410.PubMed
50.
go back to reference Jayakody K, Gunadasa S, Hosker C. Exercise for anxiety disorders: systematic review. Br J Sports Med. 2014; 48: 187-196.PubMed Jayakody K, Gunadasa S, Hosker C. Exercise for anxiety disorders: systematic review. Br J Sports Med. 2014; 48: 187-196.PubMed
51.
go back to reference Focht BC, Koltyn KF. Influence of resistance exercise of different intensities on state anxiety and blood pressure. Med Sci Sports Exerc. 1999; 31: 456-463.PubMed Focht BC, Koltyn KF. Influence of resistance exercise of different intensities on state anxiety and blood pressure. Med Sci Sports Exerc. 1999; 31: 456-463.PubMed
52.
go back to reference Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003; 83: 713-721.PubMed Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003; 83: 713-721.PubMed
53.
go back to reference Annesi JJ, Gorjala S. Association of reduction in waist circumference with normalization of mood in obese women initiating exercise supported by the Coach Approach protocol. South Med J. 2010; 103: 517-521.PubMed Annesi JJ, Gorjala S. Association of reduction in waist circumference with normalization of mood in obese women initiating exercise supported by the Coach Approach protocol. South Med J. 2010; 103: 517-521.PubMed
54.
go back to reference Hale BS, Raglin JS. State anxiety responses to acute resistance training and step aerobic exercise across 8 weeks of training. J Sports Med Phys Fitness. 2002; 42: 108-112.PubMed Hale BS, Raglin JS. State anxiety responses to acute resistance training and step aerobic exercise across 8 weeks of training. J Sports Med Phys Fitness. 2002; 42: 108-112.PubMed
55.
go back to reference Smith JA, Greer T, Sheets T, Watson S. Is there more to yoga than exercise? Altern Ther Health Med. 2011; 17: 22-29.PubMed Smith JA, Greer T, Sheets T, Watson S. Is there more to yoga than exercise? Altern Ther Health Med. 2011; 17: 22-29.PubMed
56.
go back to reference Mussgay L, Schmidt F, Morad E, Ruddel H. Does aerobic exercise modulate baroreflex sensitivity in patients with anxiety and somatization disorders? Homeost Health Dis. 2003; 42: 277-287. Mussgay L, Schmidt F, Morad E, Ruddel H. Does aerobic exercise modulate baroreflex sensitivity in patients with anxiety and somatization disorders? Homeost Health Dis. 2003; 42: 277-287.
57.
go back to reference Oeland A-M, Laessoe U, Olesen AV, Munk-Jorgensen P. Impact of exercise on patients with depression and anxiety. Nordic J Psychiatry. 2010; 64: 210-217. Oeland A-M, Laessoe U, Olesen AV, Munk-Jorgensen P. Impact of exercise on patients with depression and anxiety. Nordic J Psychiatry. 2010; 64: 210-217.
58.
go back to reference Wedekind D, Sprute A, Broocks A, et al. Nocturnal urinary cortisol excretion over a randomized controlled trial with paroxetine vs. placebo combined with relaxation training or aerobic exercise in panic disorder. Curr Pharm Des. 2008; 14: 3518-3524.PubMed Wedekind D, Sprute A, Broocks A, et al. Nocturnal urinary cortisol excretion over a randomized controlled trial with paroxetine vs. placebo combined with relaxation training or aerobic exercise in panic disorder. Curr Pharm Des. 2008; 14: 3518-3524.PubMed
59.
go back to reference Gaul-Alacova P, Boucek J, Stejskal P, et al. Assessment of the influence of exercise on heart rate variability in anxiety patients. Neuroendocrinol Lett. 2005; 26: 713-718.PubMed Gaul-Alacova P, Boucek J, Stejskal P, et al. Assessment of the influence of exercise on heart rate variability in anxiety patients. Neuroendocrinol Lett. 2005; 26: 713-718.PubMed
60.
go back to reference Lambert RA, Harvey I, Poland F. A pragmatic, unblinded randomised controlled trial comparing an occupational therapy-led lifestyle approach and routine GP care for panic disorder treatment in primary care. J Affect Disord. 2007; 99: 63-71.PubMed Lambert RA, Harvey I, Poland F. A pragmatic, unblinded randomised controlled trial comparing an occupational therapy-led lifestyle approach and routine GP care for panic disorder treatment in primary care. J Affect Disord. 2007; 99: 63-71.PubMed
61.
go back to reference Kim J-H, Yang H, Schroeppel S. A pilot study examining the effects of Kouk Sun Do on university students with anxiety symptoms. Stress Health. 2013; 29: 99-107.PubMed Kim J-H, Yang H, Schroeppel S. A pilot study examining the effects of Kouk Sun Do on university students with anxiety symptoms. Stress Health. 2013; 29: 99-107.PubMed
62.
go back to reference Faulkner J, Westrupp N, Rousseau J, Lark S. A randomized controlled trial to assess the effect of self-paced walking on task-specific anxiety in cardiac rehabilitation patients. J Cardiopulm Rehabil Prev. 2013; 33: 292-296.PubMed Faulkner J, Westrupp N, Rousseau J, Lark S. A randomized controlled trial to assess the effect of self-paced walking on task-specific anxiety in cardiac rehabilitation patients. J Cardiopulm Rehabil Prev. 2013; 33: 292-296.PubMed
63.
go back to reference Martinsen EW, Hoffart A, Solberg OY. Aerobic and non-aerobic forms of exercise in the treatment of anxiety disorders. Stress Med. 1989; 5: 115-120. Martinsen EW, Hoffart A, Solberg OY. Aerobic and non-aerobic forms of exercise in the treatment of anxiety disorders. Stress Med. 1989; 5: 115-120.
64.
go back to reference Murphy SM, Edwards RT, Williams N, et al. An evaluation of the effectiveness and cost effectiveness of the National Exercise Referral Scheme in Wales, UK: a randomised controlled trial of a public health policy initiative. J Epidemiol Community Health. 2012; 66: 745-753.PubMedCentralPubMed Murphy SM, Edwards RT, Williams N, et al. An evaluation of the effectiveness and cost effectiveness of the National Exercise Referral Scheme in Wales, UK: a randomised controlled trial of a public health policy initiative. J Epidemiol Community Health. 2012; 66: 745-753.PubMedCentralPubMed
65.
go back to reference Sexton H, Maere A, Dahl NH. Exercise intensity and reduction in neurotic symptoms: a controlled follow-up study. Acta Psychiatr Scand. 1989; 80: 231-235.PubMed Sexton H, Maere A, Dahl NH. Exercise intensity and reduction in neurotic symptoms: a controlled follow-up study. Acta Psychiatr Scand. 1989; 80: 231-235.PubMed
66.
go back to reference Goldstein-Shirley J, Brown M. Intervention of light, exercise and vitamins for mixed anxiety-depression. Communicating Nursing Research. Palm Springs, CA; 2002. Goldstein-Shirley J, Brown M. Intervention of light, exercise and vitamins for mixed anxiety-depression. Communicating Nursing Research. Palm Springs, CA; 2002.
67.
go back to reference Bandelow B, Broocks A, Pekrun G, et al. The use of the Panic and Agoraphobia Scale (P & A) in a controlled clinical trial. Pharmacopsychiatry. 2000; 33: 174-181.PubMed Bandelow B, Broocks A, Pekrun G, et al. The use of the Panic and Agoraphobia Scale (P & A) in a controlled clinical trial. Pharmacopsychiatry. 2000; 33: 174-181.PubMed
68.
go back to reference Broocks A, Bandelow B, Pekrun G, et al. Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder. Am J Psychiatr. 1998; 155: 603-609.PubMed Broocks A, Bandelow B, Pekrun G, et al. Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder. Am J Psychiatr. 1998; 155: 603-609.PubMed
69.
go back to reference Broocks A, Meyer T, Opitz M, et al. 5-HT1A responsivity in patients with panic disorder before and after treatment with aerobic exercise, clomipramine or placebo. Eur Neuropsychopharmacol. 2003; 13: 153-164.PubMed Broocks A, Meyer T, Opitz M, et al. 5-HT1A responsivity in patients with panic disorder before and after treatment with aerobic exercise, clomipramine or placebo. Eur Neuropsychopharmacol. 2003; 13: 153-164.PubMed
70.
go back to reference Goldin P, Ziv M, Jazaieri H, Gross JJ. Randomized controlled trial of mindfulness-based stress reduction versus aerobic exercise: effects on the self-referential brain network in social anxiety disorder. Front Hum Neurosci. 2012. Goldin P, Ziv M, Jazaieri H, Gross JJ. Randomized controlled trial of mindfulness-based stress reduction versus aerobic exercise: effects on the self-referential brain network in social anxiety disorder. Front Hum Neurosci. 2012.
71.
go back to reference Goldin P, Ziv M, Jazaieri H, Hahn K, Gross JJ. MBSR vs aerobic exercise in social anxiety: fMRI of emotion regulation of negative self-beliefs. Soc Cogn Affect Neurosci. 2013; 8: 65-72.PubMedCentralPubMed Goldin P, Ziv M, Jazaieri H, Hahn K, Gross JJ. MBSR vs aerobic exercise in social anxiety: fMRI of emotion regulation of negative self-beliefs. Soc Cogn Affect Neurosci. 2013; 8: 65-72.PubMedCentralPubMed
72.
go back to reference Jazaieri H, Goldin PR, Werner K, Ziv M, Gross JJ. A randomized trial of MBSR versus aerobic exercise for social anxiety disorder. J Clin Psychol. 2012; 68: 715-731.PubMedCentralPubMed Jazaieri H, Goldin PR, Werner K, Ziv M, Gross JJ. A randomized trial of MBSR versus aerobic exercise for social anxiety disorder. J Clin Psychol. 2012; 68: 715-731.PubMedCentralPubMed
73.
go back to reference Herring MP, Jacob ML, Suveg C, Dishman RK, O’Connor PJ. Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. Psychother Psychosom. 2012; 81: 21-28.PubMed Herring MP, Jacob ML, Suveg C, Dishman RK, O’Connor PJ. Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. Psychother Psychosom. 2012; 81: 21-28.PubMed
74.
go back to reference Herring MP, Jacob ML, Suveg C, O’Connor PJ. Effects of short-term exercise training on signs and symptoms of generalized anxiety disorder. Ment Health Phys Act. 2011; 4: 71-77. Herring MP, Jacob ML, Suveg C, O’Connor PJ. Effects of short-term exercise training on signs and symptoms of generalized anxiety disorder. Ment Health Phys Act. 2011; 4: 71-77.
75.
go back to reference Merom D, Phongsavan P, Wagner R, et al. Promoting walking as an adjunct intervention to group cognitive behavioral therapy for anxiety disorders—a pilot group randomized trial. J Anxiety Disord. 2008; 22: 959-968.PubMed Merom D, Phongsavan P, Wagner R, et al. Promoting walking as an adjunct intervention to group cognitive behavioral therapy for anxiety disorders—a pilot group randomized trial. J Anxiety Disord. 2008; 22: 959-968.PubMed
76.
go back to reference Phongsavan P, Merom D, Wagner R, et al. Process evaluation in an intervention designed to promote physical activity among adults with anxiety disorders: evidence of acceptability and adherence. Health Promot J Aust. 2008; 19: 137-143. Phongsavan P, Merom D, Wagner R, et al. Process evaluation in an intervention designed to promote physical activity among adults with anxiety disorders: evidence of acceptability and adherence. Health Promot J Aust. 2008; 19: 137-143.
77.
go back to reference Oldridge N, Guyatt G, Jones N, et al. Effects on quality of life with comprehensive rehabilitation after acute myocardial infarction. Am J Cardiol. 1991; 67: 1084-1089.PubMed Oldridge N, Guyatt G, Jones N, et al. Effects on quality of life with comprehensive rehabilitation after acute myocardial infarction. Am J Cardiol. 1991; 67: 1084-1089.PubMed
78.
go back to reference Oldridge N, Streiner D, Hoffmann R, Guyatt G. Profile of mood states and cardiac rehabilitation after acute myocardial infarction. Med Sci Sports Exerc. 1995; 27: 900-905.PubMed Oldridge N, Streiner D, Hoffmann R, Guyatt G. Profile of mood states and cardiac rehabilitation after acute myocardial infarction. Med Sci Sports Exerc. 1995; 27: 900-905.PubMed
79.
go back to reference Carmeli E, Barak S, Morad M, Kodesh E. Physical exercises can reduce anxiety and improve quality of life among adults with intellectual disability. Int Sport Med J. 2009; 10: 77-85. Carmeli E, Barak S, Morad M, Kodesh E. Physical exercises can reduce anxiety and improve quality of life among adults with intellectual disability. Int Sport Med J. 2009; 10: 77-85.
80.
go back to reference Kim SH, Schneider SM, Bevans M, et al. PTSD symptom reduction with mindfulness-based stretching and deep breathing exercise: randomized controlled clinical trial of efficacy. J Clin Endocrinol Metab. 2013; 98: 2984-2992.PubMedCentralPubMed Kim SH, Schneider SM, Bevans M, et al. PTSD symptom reduction with mindfulness-based stretching and deep breathing exercise: randomized controlled clinical trial of efficacy. J Clin Endocrinol Metab. 2013; 98: 2984-2992.PubMedCentralPubMed
81.
go back to reference Gutiérrez CV, Luque GT, Medina GMÁ, et al. Influence of exercise on mood in postmenopausal women. J Clin Nurs. 2012; 21: 923-928. Gutiérrez CV, Luque GT, Medina GMÁ, et al. Influence of exercise on mood in postmenopausal women. J Clin Nurs. 2012; 21: 923-928.
82.
go back to reference Broman-Fulks JJ, Storey KM. Evaluation of a brief aerobic exercise intervention for high anxiety sensitivity. Anxiety Stress Coping. 2008; 21: 117-128.PubMed Broman-Fulks JJ, Storey KM. Evaluation of a brief aerobic exercise intervention for high anxiety sensitivity. Anxiety Stress Coping. 2008; 21: 117-128.PubMed
83.
go back to reference Smits JAJ, Berry AC, Rosenfield D, et al. Reducing anxiety sensitivity with exercise. Depression Anxiety. 2008; 25: 689-699.PubMed Smits JAJ, Berry AC, Rosenfield D, et al. Reducing anxiety sensitivity with exercise. Depression Anxiety. 2008; 25: 689-699.PubMed
84.
go back to reference Wedekind D, Broocks A, Weiss N, et al. A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder. World J Biol Psychiatry. 2010; 11: 904-913.PubMed Wedekind D, Broocks A, Weiss N, et al. A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder. World J Biol Psychiatry. 2010; 11: 904-913.PubMed
85.
go back to reference Hovland A, Nordhus IH, Sjobo T, et al. Comparing physical exercise in groups to group cognitive behaviour therapy for the treatment of panic disorder in a randomized controlled trial. Behav Cogn Psychother. 2013; 41: 408-432.PubMedCentralPubMed Hovland A, Nordhus IH, Sjobo T, et al. Comparing physical exercise in groups to group cognitive behaviour therapy for the treatment of panic disorder in a randomized controlled trial. Behav Cogn Psychother. 2013; 41: 408-432.PubMedCentralPubMed
86.
go back to reference Higgins JPT, Green S eds. Cochrane Handbook for Systematic Reviews of Interventions, 5.1.0 [updated March 2011]: The Cochrane Collaboration, 2011. Available at www.cochrane-handbook.org. Higgins JPT, Green S eds. Cochrane Handbook for Systematic Reviews of Interventions, 5.1.0 [updated March 2011]: The Cochrane Collaboration, 2011. Available at www.​cochrane-handbook.​org.
87.
go back to reference Jüni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. J Am Med Assoc. 1999; 282: 1054-1060. Jüni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. J Am Med Assoc. 1999; 282: 1054-1060.
88.
go back to reference Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. J Am Med Assoc. 1995; 273: 408-412. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. J Am Med Assoc. 1995; 273: 408-412.
89.
go back to reference Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959; 32: 50-55.PubMed Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959; 32: 50-55.PubMed
90.
go back to reference Beck AT, Steer RA. Manual for the Beck Anxiety Inventory. San Antonio, TX: Psychological Corporation; 1990. Beck AT, Steer RA. Manual for the Beck Anxiety Inventory. San Antonio, TX: Psychological Corporation; 1990.
91.
go back to reference Chambless DL, Caputo GC, Bright P, Gallagher R. Assessment of fear of fear in agoraphobics: the Body Sensations Questionnaire and the Agoraphobic Cognitions Questionnaire. J Consult Clin Psychol. 1984; 52: 1090-1097.PubMed Chambless DL, Caputo GC, Bright P, Gallagher R. Assessment of fear of fear in agoraphobics: the Body Sensations Questionnaire and the Agoraphobic Cognitions Questionnaire. J Consult Clin Psychol. 1984; 52: 1090-1097.PubMed
92.
go back to reference Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther. 1986; 24: 1-8.PubMed Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther. 1986; 24: 1-8.PubMed
93.
go back to reference Taylor S, Cox BJ. An expanded Anxiety Sensitivity Index: evidence for a hierarchic structure in a clinical sample. J Anxiety Disord. 1998; 12: 463-483.PubMed Taylor S, Cox BJ. An expanded Anxiety Sensitivity Index: evidence for a hierarchic structure in a clinical sample. J Anxiety Disord. 1998; 12: 463-483.PubMed
94.
go back to reference Guy W ed. ECDEU Assessment Manual for Psychopharmacology-Revised. Rockville, MD: US Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration; 1976. Guy W ed. ECDEU Assessment Manual for Psychopharmacology-Revised. Rockville, MD: US Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration; 1976.
95.
go back to reference Lovibond SH, Lovibond PF. Manual for the Depression Anxiety Stress Scales. Sydney, N.S.W: Psychology Foundation of Australia; 1995. Lovibond SH, Lovibond PF. Manual for the Depression Anxiety Stress Scales. Sydney, N.S.W: Psychology Foundation of Australia; 1995.
96.
go back to reference Fresco DM, Coles ME, Heimberg RG, et al. The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats. Psychol Med. 2001; 31: 1025-1035.PubMed Fresco DM, Coles ME, Heimberg RG, et al. The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats. Psychol Med. 2001; 31: 1025-1035.PubMed
97.
go back to reference Chambless DL, Caputo GC, Jasin SE, Gracely EJ, Williams C. The mobility inventory for agoraphobia. Behav Res Ther. 1985; 23: 35-44.PubMed Chambless DL, Caputo GC, Jasin SE, Gracely EJ, Williams C. The mobility inventory for agoraphobia. Behav Res Ther. 1985; 23: 35-44.PubMed
98.
go back to reference Bandelow B. Assessing the efficacy of treatments for panic disorder and agoraphobia. II. the Panic and Agoraphobia Scale. Int Clin Psychopharmacol. 1995; 10: 73-81.PubMed Bandelow B. Assessing the efficacy of treatments for panic disorder and agoraphobia. II. the Panic and Agoraphobia Scale. Int Clin Psychopharmacol. 1995; 10: 73-81.PubMed
99.
go back to reference Blanchard EB, Jones-Alexander J, Buckley TC, Forneris CA. Psychometric properties of the PTSD Checklist (PCL). Behav Res Ther. 1996; 34: 669-673.PubMed Blanchard EB, Jones-Alexander J, Buckley TC, Forneris CA. Psychometric properties of the PTSD Checklist (PCL). Behav Res Ther. 1996; 34: 669-673.PubMed
100.
go back to reference Weathers FW, Litz BT, Herman DS, Huska JA, Keane TM: The PTSD Checklist (PCL). Reliability, validity, and diagnostic utility. Annual Convention of the International Society for Traumatic Stress Studies. San Antonio; 1993. Weathers FW, Litz BT, Herman DS, Huska JA, Keane TM: The PTSD Checklist (PCL). Reliability, validity, and diagnostic utility. Annual Convention of the International Society for Traumatic Stress Studies. San Antonio; 1993.
101.
go back to reference McNair DM, Lorr M, Droppleman L. POMS: Profile of Mood States. North Tonawanda, NY: Multi-Health Systems Inc; 1992. McNair DM, Lorr M, Droppleman L. POMS: Profile of Mood States. North Tonawanda, NY: Multi-Health Systems Inc; 1992.
102.
go back to reference Meyer TJ, Miller ML, Metzger RL, Borkovec TD. Development and validation of the Penn State Worry Questionnaire. Behav Res Ther. 1990; 28: 487-495.PubMed Meyer TJ, Miller ML, Metzger RL, Borkovec TD. Development and validation of the Penn State Worry Questionnaire. Behav Res Ther. 1990; 28: 487-495.PubMed
103.
go back to reference Rodebaugh TL, Woods CM, Heimberg RG. The reverse of social anxiety is not always the opposite: the reverse-scored items of the Social Interaction Anxiety Scale do not belong. Behav Ther. 2007; 38: 192-206.PubMed Rodebaugh TL, Woods CM, Heimberg RG. The reverse of social anxiety is not always the opposite: the reverse-scored items of the Social Interaction Anxiety Scale do not belong. Behav Ther. 2007; 38: 192-206.PubMed
104.
go back to reference Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Inventory. Palo Alto: Consulting Psychologists Press; 1983. Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Inventory. Palo Alto: Consulting Psychologists Press; 1983.
105.
go back to reference Bartley CA, Hay M, Bloch MH. Meta-analysis: aerobic exercise for the treatment of anxiety disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 2013; 45: 34-39. Bartley CA, Hay M, Bloch MH. Meta-analysis: aerobic exercise for the treatment of anxiety disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 2013; 45: 34-39.
106.
go back to reference Petruzzello SJ, Landers DM, Hatfield BD, Kubitz KA, Salazar W. A meta-analysis on the anxiety-reducing effects of acute and chronic exercise: outcomes and mechanisms. Sports Med. 1991; 11: 143-182.PubMed Petruzzello SJ, Landers DM, Hatfield BD, Kubitz KA, Salazar W. A meta-analysis on the anxiety-reducing effects of acute and chronic exercise: outcomes and mechanisms. Sports Med. 1991; 11: 143-182.PubMed
107.
go back to reference Santor DA, Zuroff DC, Ramsay JO, Cervantes P, Palacios J. Examining scale discriminability in the BDI and CES-D as a function of depressive severity. Psychol Assess. 1995; 7: 131-139. Santor DA, Zuroff DC, Ramsay JO, Cervantes P, Palacios J. Examining scale discriminability in the BDI and CES-D as a function of depressive severity. Psychol Assess. 1995; 7: 131-139.
108.
go back to reference Slade T, Andrews G. Latent structure of depression in a community sample: a taxometric analysis. Psychol Med. 2005; 35: 489-497.PubMed Slade T, Andrews G. Latent structure of depression in a community sample: a taxometric analysis. Psychol Med. 2005; 35: 489-497.PubMed
109.
go back to reference Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO. Exercise treatment for depression: efficacy and dose response. Am J Prev Med. 2005; 28: 1-8.PubMed Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO. Exercise treatment for depression: efficacy and dose response. Am J Prev Med. 2005; 28: 1-8.PubMed
110.
go back to reference Bartholomew J, Linder D. State anxiety following resistance exercise: the role of gender and exercise intensity. J Behav Med. 1998; 21: 205-219.PubMed Bartholomew J, Linder D. State anxiety following resistance exercise: the role of gender and exercise intensity. J Behav Med. 1998; 21: 205-219.PubMed
111.
go back to reference Broman-Fulks JJ, Berman ME, Rabian BA, Webster MJ. Effects of aerobic exercise on anxiety sensitivity. Behav Res Ther. 2004; 42: 125-136.PubMed Broman-Fulks JJ, Berman ME, Rabian BA, Webster MJ. Effects of aerobic exercise on anxiety sensitivity. Behav Res Ther. 2004; 42: 125-136.PubMed
112.
go back to reference Masters KS, Spielmans GI, LaCaille RA, et al. Effects of home exercise on immediate and delayed affect and mood among rural individuals at risk for type 2 diabetes. J Soc Behav Health Sci. 2011; 5: 1-16. Masters KS, Spielmans GI, LaCaille RA, et al. Effects of home exercise on immediate and delayed affect and mood among rural individuals at risk for type 2 diabetes. J Soc Behav Health Sci. 2011; 5: 1-16.
113.
114.
go back to reference Arch JJ, Craske MG. Acceptance and commitment therapy and cognitive behavioral therapy for anxiety disorders: different treatments, similar mechanisms? Clin Psychol Sci Pract. 2008; 15: 263-279. Arch JJ, Craske MG. Acceptance and commitment therapy and cognitive behavioral therapy for anxiety disorders: different treatments, similar mechanisms? Clin Psychol Sci Pract. 2008; 15: 263-279.
115.
go back to reference Rosenthal R. The file drawer problem and tolerance for null results. Psychol Bull. 1979; 86: 638-641. Rosenthal R. The file drawer problem and tolerance for null results. Psychol Bull. 1979; 86: 638-641.
116.
go back to reference Easterbrook PJ, Gopalan R, Berlin JA, Matthews DR. Publication bias in clinical research. Lancet. 1991; 337: 867-872.PubMed Easterbrook PJ, Gopalan R, Berlin JA, Matthews DR. Publication bias in clinical research. Lancet. 1991; 337: 867-872.PubMed
Metadata
Title
Exercise as Treatment for Anxiety: Systematic Review and Analysis
Authors
Gregory L. Stonerock, Ph.D.
Benson M. Hoffman, Ph.D.
Patrick J. Smith, Ph.D.
James A. Blumenthal, Ph.D.
Publication date
01-08-2015
Publisher
Springer US
Published in
Annals of Behavioral Medicine / Issue 4/2015
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-014-9685-9

Other articles of this Issue 4/2015

Annals of Behavioral Medicine 4/2015 Go to the issue