Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 1/2014

01-08-2014 | Original Article

Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis

Authors: Matthew S. Herbert, M.A., Burel R. Goodin, Ph.D., Samuel T. Pero IV, B.S., Jessica K. Schmidt, B.A., Adriana Sotolongo, M.P.H., Hailey W. Bulls, B.S., Toni L. Glover, Ph.D., GNP-BC, Christopher D. King, Ph.D., Kimberly T. Sibille, Ph.D., Yenisel Cruz-Almeida, M.S.P.H., Ph.D., Roland Staud, M.D., Barri J. Fessler, M.D., M.S.P.H., Laurence A. Bradley, Ph.D., Roger B. Fillingim, Ph.D.

Published in: Annals of Behavioral Medicine | Issue 1/2014

Login to get access

Abstract

Background

Pain hypervigilance is an important aspect of the fear-avoidance model of pain that may help explain individual differences in pain sensitivity among persons with knee osteoarthritis (OA).

Purpose

The purpose of this study was to examine the contribution of pain hypervigilance to clinical pain severity and experimental pain sensitivity in persons with symptomatic knee OA.

Methods

We analyzed cross-sectional data from 168 adults with symptomatic knee OA. Quantitative sensory testing was used to measure sensitivity to heat pain, pressure pain, and cold pain, as well as temporal summation of heat pain, a marker of central sensitization.

Results

Pain hypervigilance was associated with greater clinical pain severity, as well as greater pressure pain. Pain hypervigilance was also a significant predictor of temporal summation of heat pain.

Conclusions

Pain hypervigilance may be an important contributor to pain reports and experimental pain sensitivity among persons with knee OA.
Literature
1.
Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: A systemic search and summary of the literature. BMC Musculoskelet Disord. 2009; 9: 116.CrossRef
2.
Hannan MT, Felson DT, Pincus T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol. 2000; 27: 1513-1517.PubMed
3.
Kim KW, Han JW, Cho HJ, et al. Association between comorbid depression and osteoarthritis symptom severity in patients with knee osteoarthritis. J Bone Joint Surg Am. 2011; 93: 556-563.PubMedCrossRef
4.
Steultjens MP, Dekker J, Bijlsma JW. Coping, pain, and disability in osteoarthritis: A longitudinal study. J Rheumatol. 2001; 28: 1068-1072.PubMed
5.
Williams DA, Farrell MJ, Cunningham J, et al. Knee pain and radiographic osteoarthritis interact in the prediction of levels of self-reported disability. Arthritis Rheum. 2004; 15: 558-561.CrossRef
6.
Leeuw M, Goossens ME, Linton SJ, Crombez G, Boersma K, Vlaeyen JW. The fear-avoidance model of musculoskeletal pain: Current state of scientific evidence. J Behav Med. 2007; 30: 77-94.PubMedCrossRef
7.
8.
Crombez G, Van Damme S, Eccleston C. Hypervigilance to pain: An experimental and clinical analysis. Pain. 2005; 116: 4-7.PubMedCrossRef
9.
McCracken LM. Attention to pain in persons with chronic pain: A behavioural approach. Behav Ther. 1997; 28: 271-284.CrossRef
10.
McDermid AJ, Rollman GB, McCain GA. Generalized hypervigilance in fibromyalgia: Evidence of perceptual amplification. Pain. 1996; 66: 133-144.PubMedCrossRef
11.
12.
Meeus M, Vervisch S, De Clerck LS, Moorkens G, Hans G, Nijs J. Central sensitization in patients with rheumatoid arthritis: A systematic literature review. Semin Arthritis Rheum. 2012; 41: 556-567.PubMedCrossRef
13.
14.
Gwilym SE, Keltner JR, Warnaby CE, et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 2009; 15: 1226-1234.CrossRef
15.
Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011; 13: 211.PubMedCentralPubMedCrossRef
16.
Meeus M, Nijs J. Central sensitization: A biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clin Rheumatol. 2007; 26: 465-473.PubMedCentralPubMedCrossRef
17.
Staud R, Craggs JG, Robinson ME, Perlstein WM, Price DD. Brain activity related to temporal summation of C-fiber evoked pain. Pain. 2007; 129: 130-142.PubMedCentralPubMedCrossRef
18.
Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee. Arthritis Rheum. 1986; 29: 1039-1049.PubMedCrossRef
19.
Roelofs J, Peters ML, McCracken L, Vlaeyen JW. The pain vigilance and awareness questionnaire (PVAQ): Further psychometric evaluation in fibromyalgia and other chronic pain syndromes. Pain. 2003; 101: 299-306.PubMedCrossRef
20.
Roelofs J, Peters ML, Muris P, Vlaeyen JW. Dutch version of the Pain Vigilance and Awareness Questionnaire: Validity and reliability in a pain-free population. Behav Res Ther. 2002; 40: 1081-1090.PubMedCrossRef
21.
Radloff LS. The CES-D scale: A self report depression scale for research in the general population. Appl Psychol Meas. 1977; 1: 385-401.CrossRef
22.
Smarr KL, Keefer AL. Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Arthritis Care Res (Hoboken). 2011; 63: S454-S466.CrossRef
23.
Turk DC, Okifuji A. Detecting depression in chronic pain patients: Adequacy of self-reports. Behav Res Ther. 1994; 32: 9-16.PubMedCrossRef
24.
Edwards RR, Campbell CM, Fillingim RB. Catastrophizing and experimental pain sensitivity: Only in vivo reports of catastrophic cognitions correlate with pain responses. J Pain. 2005; 6: 338-339.PubMedCrossRef
25.
Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip and knee. J Rheumatol. 1988; 15: 1833-1840.PubMed
26.
Collins NJ, Misra D, Felson DT, Crossley KM, Roos EM. Measures of knee function: International Knee Documentation Committee (IKDC) subjective knee evaluation form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short From (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS). Arthritis Care Res. 2011; 63: S208-S228.CrossRef
27.
Edwards RR, Ness TJ, Weigent DA, Fillingim RB. Individual differences in diffuse noxious inhibitory controls (DNIC): Association with clinical variables. Pain. 2003; 106: 427-437.PubMedCrossRef
28.
Finnerup NB, Sindrup SH, Bach FW, Johannesen IL, Jensen TS. Lamotrigine in spinal cord injury pain: A randomized controlled trial. Pain. 2002; 96: 375-383.PubMedCrossRef
29.
Wallace MS, Rowbotham MC, Katz NP, et al. A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. Neurology. 2002; 59: 1694-1700.PubMedCrossRef
30.
Abdi H. Holm’s Sequential Bonferroni Procedure. Thousand Oaks, CA: Sage; 2010.
31.
Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Erlbaum; 1988.
32.
Eysenck MW. Anxiety: The Cognitive Perspective. East Sussex, UK: Lawrence Erlbaum Associated Ltd.; 1992.
33.
Crombez G, Viane I, Eccleston C, Devulder J, Goubert L. Attention to pain and fear of pain in patients with chronic pain. J Behav Med. 2013; 36: 371-378.PubMedCrossRef
34.
Keefe FJ, Caldwell DS, Williams DA, et al. Pain coping skills training in the management of osteoarthritic knee pain: A comparative study. Behav Ther. 1990; 21: 49-62.CrossRef
35.
Keefe FJ, Blumenthal J, Baucom D, et al. Effects of spouse-assisted coping skills training and exercise training in patients with osteoarthritic knee pain: A randomized controlled study. Pain. 2004; 110: 539-549.PubMedCrossRef
36.
de Jong JR, Vlaeyen JW, Onghena P, Goossens ME, Geilen M, Mulder H. Fear of movement/(re)injury in chronic low back pain: Education or exposure in vivo as mediator to fear reduction? Clin J Pain. 2005; 21: 9-17.PubMedCrossRef
37.
Vlaeyen JWS, de Jong JR, Sieben J, Crombez G. Graded exposure in vivo for pain-related fear. In: Gatchel R, Turk DC, eds. Psychological Approaches to Pain Management. New York: Guilford; 2002.
38.
Arendt-Nielsen L, Nie H, Laursen MB, et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010; 149: 573-581.PubMedCrossRef
39.
Imamura M, Imamura ST, Kaziyama HH, et al. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis. Arthritis Rheum. 2008; 15: 1424-1431.CrossRef
40.
Finan PH, Buenaver LF, Bounds SC, et al. Discordance between pain and radiographic severity in knee osteoarthritis: Findings from quantitative sensory testing of central sensitization. Arthritis Rheum. 2013; 65: 363-372.PubMedCrossRef
41.
Straube T, Schmidt S, Weiss T, Mentzel HJ, Miltner WH. Dynamic activation of the anterior cingulate cortex during anticipatory anxiety. Neuroimage. 2009; 44: 975-981.PubMedCrossRef
42.
Kalkarni B, Bentley DE, Elliott R, et al. Arthritis pain is processed in brain areas concerned with emotions and fear. Arthritis Rheum. 2007; 56: 1345-1354.CrossRef
43.
Kong J, Tu PC, Zyloney C, Su TP. Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study. Behav Brain Res. 2010; 25: 215-219.CrossRef
44.
45.
Rahim-Williams B, Riley JL, Williams AK, Fillingim RB. A quantitative review of ethnic group differences in experimental pain response: Do biology, psychology, and culture matter? Pain Med. 2012; 13: 522-540.PubMedCentralPubMedCrossRef
46.
Wang AK, Gillen DA, Dyck PJ. Effect of simple analgesics on quantitative sensation test threshold. Neurology. 1999; 53: 1865-186.PubMedCrossRef
Metadata
Title
Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis
Authors
Matthew S. Herbert, M.A.
Burel R. Goodin, Ph.D.
Samuel T. Pero IV, B.S.
Jessica K. Schmidt, B.A.
Adriana Sotolongo, M.P.H.
Hailey W. Bulls, B.S.
Toni L. Glover, Ph.D., GNP-BC
Christopher D. King, Ph.D.
Kimberly T. Sibille, Ph.D.
Yenisel Cruz-Almeida, M.S.P.H., Ph.D.
Roland Staud, M.D.
Barri J. Fessler, M.D., M.S.P.H.
Laurence A. Bradley, Ph.D.
Roger B. Fillingim, Ph.D.
Publication date
01-08-2014
Publisher
Springer US
Published in
Annals of Behavioral Medicine / Issue 1/2014
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-013-9563-x

Other articles of this Issue 1/2014

Annals of Behavioral Medicine 1/2014 Go to the issue

Original Article

Disgusted, Embarrassed, Annoyed: Affective Associations Relate to Uptake of Colonoscopy Screening

Invited Commentary

The Causes and Consequences of HIV-Related Enacted and Internalized Stigma: a Comment on Takada et al.

Original Article

Prospective Examination of Cigarette Smoking Among Iraq-Deployed and Nondeployed Soldiers: Prevalence and Predictive Characteristics

Original Article

Stress-Related Clinical Pain and Mood in Women with Chronic Pain: Moderating Effects of Depression and Positive Mood Induction

Invited Commentary

Nutrient-Specific Perceptions of Food Healthiness and the Role of Nutrition Knowledge: A Comment on Rizk and Treat

Original Article

The Impact of Incentives on Exercise Behavior: A Systematic Review of Randomized Controlled Trials