01-06-2012 | Original Article
Association Between Type D Personality and Prognosis in Patients with Cardiovascular Diseases: a Systematic Review and Meta-analysis
Published in: Annals of Behavioral Medicine | Issue 3/2012
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Background
Since 1995, the association of type D personality and mortality in patients with cardiovascular diseases has been increasingly investigated.
Purpose
The aim of this meta-analysis was to integrate conflicting results and to examine possible moderators of this association.
Methods
Prospective studies assessing type D personality and hard endpoints were selected and pooled in meta-analyses. Cardiovascular diagnosis, type and quality of adjustment, and publication date were examined in moderator analyses.
Results
Twelve studies on patients with cardiovascular diseases (N = 5,341) were included. Pooled crude and adjusted effects demonstrated a significant association of type D personality and hard endpoints (odds ratio (OR) of 2.28 (95% CI [1.43–3.62]), adjusted hazard ratio (HR) of 2.24 (95% CI [1.37–3.66])). The OR decreased over time (OR 5.02 to OR 1.54). There was no association in congestive heart failure patients.
Conclusions
More recent methodologically sound studies suggest that early type D studies had overestimated the prognostic relevance.