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Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 1/2010

01-08-2010 | Original Article

Patient Expectancy and Post-chemotherapy Nausea: A Meta-analysis

Published in: Annals of Behavioral Medicine | Issue 1/2010

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Abstract

Background

Post-chemotherapy nausea remains a significant burden to cancer patients. While some studies indicate that expecting nausea is predictive of experiencing nausea, there are a number of conflicting findings.

Purpose

The purpose of this study was to conduct a meta-analytic review to determine the strength of the relationship between expectancy and post-chemotherapy nausea.

Methods

The findings from 17 relevant studies (n = 2,400) identified through systematic searches of Medline, PsycInfo, and Cinhal were analyzed using a combination of meta-analytic techniques.

Results

Overall, there was a robust positive association between expectancy and post-chemotherapy nausea (ESr = 0.18, equivalent to Cohen’s d = 0.35), suggesting that patients with stronger expectancies experience more chemotherapy-induced nausea. Although weaker associations were found in studies employing multivariate analysis, specifically controlling for a history of nausea, and involving breast cancer patients, none of the moderators assessed were statistically significant.

Conclusions

These findings suggest that patient expectancies may contribute to post-chemotherapy nausea and that expectancy-based manipulations may provide a useful intervention strategy.
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Metadata
Title
Patient Expectancy and Post-chemotherapy Nausea: A Meta-analysis
Publication date
01-08-2010
Published in
Annals of Behavioral Medicine / Issue 1/2010
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-010-9186-4

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