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Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 3/2008

01-06-2008 | Original Article

Physical Sequelae and Depressive Symptoms in Gynecologic Cancer Survivors: Meaning in Life as a Mediator

Authors: Laura E. Simonelli, Ph.D., Jeffrey Fowler, M.D., G. Larry Maxwell, M.D., Barbara L. Andersen, Ph.D.

Published in: Annals of Behavioral Medicine | Issue 3/2008

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Abstract

Background

Continuing symptoms and poor health following cancer treatments may alter meaning in life for cancer survivors. Gynecologic cancer survivors are particularly troubled with physical sequelae. In addition, for the most common sites of disease, such as breast and gynecologic cancers, the prevalence of depression is also high.

Purpose

This study tests meaning in life as a mechanism for the relationship between physical symptoms and depressive symptoms.

Methods

Gynecologic cancer survivors (N = 260) participated. Measures of physical sequelae (nurse rated symptoms/signs, patient-reported gynecologic symptoms), meaning in life (harmony, life purpose, spirituality, and conversely, confusion and loss), and depressive symptoms were obtained at the time of a routine clinical follow-up visit 2–10 years following the completion of treatment. Latent variables were defined, and structural equation modeling tested a mediator model.

Results

Analyses support partial mediation. That is, survivors with more physical sequelae also reported lower levels of meaning in life, which was associated with higher levels of depressive symptoms.

Conclusions

Gynecologic cancer patients have been neglected in psychosocial research, and findings highlight the importance of existential issues in their lives. While many adjust well, those with persistent physical functioning deficits may experience depressive symptoms. By appreciating the role of meaning in their experience, we may help survivors foster their own growth and perspectives important for their future.
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Metadata
Title
Physical Sequelae and Depressive Symptoms in Gynecologic Cancer Survivors: Meaning in Life as a Mediator
Authors
Laura E. Simonelli, Ph.D.
Jeffrey Fowler, M.D.
G. Larry Maxwell, M.D.
Barbara L. Andersen, Ph.D.
Publication date
01-06-2008
Publisher
Springer-Verlag
Published in
Annals of Behavioral Medicine / Issue 3/2008
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-008-9029-8

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