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01-07-2018 | Original Article

The correlation between striatal and cortical binding ratio of ¹¹C-PiB-PET in amyloid-uptake-positive patients

Authors: Julia Sauerbeck, Kazunari Ishii, Chisa Hosokawa, Hayato Kaida, Franziska T. Scheiwein, Kohei Hanaoka, Axel Rominger, Matthias Brendel, Peter Bartenstein, Takamichi Murakami

Published in: Annals of Nuclear Medicine | Issue 6/2018

Abstract

Purpose

In subjects with amyloid deposition, striatal accumulation of ¹¹C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer’s disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BP_ND).

Methods

Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson’s disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BP_ND images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BP_ND measures.

Results

There were highly significant correlations between striatal and prefrontal BP_ND, with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BP_ND values correlated with striatal BP_ND values, with the exception of the occipital cortex with low correlation.

Conclusion

Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections.

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Title: The correlation between striatal and cortical binding ratio of 11C-PiB-PET in amyloid-uptake-positive patients
Authors: Julia Sauerbeck
Kazunari Ishii
Chisa Hosokawa
Hayato Kaida
Franziska T. Scheiwein
Kohei Hanaoka
Axel Rominger
Matthias Brendel
Peter Bartenstein
Takamichi Murakami
Publication date: 01-07-2018
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 6/2018
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-018-1258-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The correlation between striatal and cortical binding ratio of ¹¹C-PiB-PET in amyloid-uptake-positive patients

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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