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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 5/2018

01-06-2018 | Original Article

CT-based attenuation correction and resolution compensation for I-123 IMP brain SPECT normal database: a multicenter phantom study

Authors: Yoshitaka Inui, Takashi Ichihara, Masaki Uno, Masanobu Ishiguro, Kengo Ito, Katsuhiko Kato, Hajime Sakuma, Hidehiko Okazawa, Hiroshi Toyama

Published in: Annals of Nuclear Medicine | Issue 5/2018

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Abstract

Objective

Statistical image analysis of brain SPECT images has improved diagnostic accuracy for brain disorders. However, the results of statistical analysis vary depending on the institution even when they use a common normal database (NDB), due to different intrinsic spatial resolutions or correction methods. The present study aimed to evaluate the correction of spatial resolution differences between equipment and examine the differences in skull bone attenuation to construct a common NDB for use in multicenter settings.

Methods

The proposed acquisition and processing protocols were those routinely used at each participating center with additional triple energy window (TEW) scatter correction (SC) and computed tomography (CT) based attenuation correction (CTAC). A multicenter phantom study was conducted on six imaging systems in five centers, with either single photon emission computed tomography (SPECT) or SPECT/CT, and two brain phantoms. The gray/white matter I-123 activity ratio in the brain phantoms was 4, and they were enclosed in either an artificial adult male skull, 1300 Hounsfield units (HU), a female skull, 850 HU, or an acrylic cover. The cut-off frequency of the Butterworth filters was adjusted so that the spatial resolution was unified to a 17.9 mm full width at half maximum (FWHM), that of the lowest resolution system. The gray-to-white matter count ratios were measured from SPECT images and compared with the actual activity ratio. In addition, mean, standard deviation and coefficient of variation images were calculated after normalization and anatomical standardization to evaluate the variability of the NDB.

Results

The gray-to-white matter count ratio error without SC and attenuation correction (AC) was significantly larger for higher bone densities (p < 0.05). The count ratio error with TEW and CTAC was approximately 5% regardless of bone density. After adjustment of the spatial resolution in the SPECT images, the variability of the NDB decreased and was comparable to that of the NDB without correction.

Conclusion

The proposed protocol showed potential for constructing an appropriate common NDB from SPECT images with SC, AC and spatial resolution compensation.
Appendix
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Metadata
Title
CT-based attenuation correction and resolution compensation for I-123 IMP brain SPECT normal database: a multicenter phantom study
Authors
Yoshitaka Inui
Takashi Ichihara
Masaki Uno
Masanobu Ishiguro
Kengo Ito
Katsuhiko Kato
Hajime Sakuma
Hidehiko Okazawa
Hiroshi Toyama
Publication date
01-06-2018
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 5/2018
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-018-1248-x

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