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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 7/2017

01-08-2017 | Original Article

FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study

Authors: Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa

Published in: Annals of Nuclear Medicine | Issue 7/2017

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Abstract

Objectives

We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment 18F-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on long-term follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival.

Methods

A total of 81 patients were enrolled. The survival rate was calculated by the Kaplan–Meier method. Both univariate and multivariate survival analyses were assessed by a Cox proportional hazards model.

Results

SUVmax ≥15.2 in institution A (p = 0.0306) or SUVmax ≥8 in institution B (p = 0.0132) was significantly predictor of a lower OS. We disaggregated the data by high SUVmax (SUVmax ≥15.2 from institution A and SUVmax ≥8 from institution B) and low SUVmax (SUVmax <15.2 from institution A and SUVmax <8 from institution B). Patients with a high SUVmax exhibited a significantly lower OS in both univariate (p = 0.001) and multivariate (p = 0.0046) analyses for adjusted for the clinical stage and treatment group. The patients with a high SUVmax exhibited significantly shorter disease-specific (p = 0.0068), distant metastasis-free (p = 0.0428), and lung metastasis-free (p = 0.0328) survivals.

Conclusions

High SUVmax was significantly correlated with a lower OS, disease-specific survival, distant metastasis-free survival, and lung metastasis-free survival in a multi-institutional retrospective study.
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Metadata
Title
FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study
Authors
Hidenori Suzuki
Katsuhiko Kato
Masami Nishio
Tsuneo Tamaki
Yasushi Fujimoto
Mariko Hiramatsu
Nobuhiro Hanai
Takeshi Kodaira
Yoshiyuki Itoh
Shinji Naganawa
Michihiko Sone
Yasuhisa Hasegawa
Publication date
01-08-2017
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 7/2017
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-017-1176-1

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