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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 5/2016

01-06-2016 | Original Article

Prognostic value of pre-operative glucose-corrected maximum standardized uptake value in patients with non-small cell lung cancer after complete surgical resection and 5-year follow-up

Authors: Renske Konings, Matthijs H. van Gool, Martin P. L. Bard, Anthonie Zwijnenburg, Bart M. Titulaer, Tjeerd S. Aukema, Renato A. Valdés Olmos, Karolina Sikorska, Houke M. Klomp, Herman Rijna

Published in: Annals of Nuclear Medicine | Issue 5/2016

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Abstract

Introduction

In this study we evaluated the value of pre-operative glucose corrected maximum standard uptake value (GC-SUVmax) as prognostic factor in patients with early stage non-small cell lung cancer (NSCLC) after complete surgical resection.

Methods

This study was designed as a retrospectively evaluated single center study with prospective data registry. Inclusion criteria were: histologically proven stage I NSCLC, 18F-FDG-PET/CT scan prior to surgery, complete resection (R0) and follow up in our outpatient department. Exclusion criteria were: history of malignancy other than NSCLC, diabetes and (neo) adjuvant therapy. Follow up period was 5 years.

Results

Between 2006 and 2008 a total of 33 patients (16 males, 17 females) met the inclusion criteria. SUVmax and GC-SUVmax were strongly correlated (Spearman’s ρ = 0.97). Five-year overall survival (OS) rate was 70 % (95 % CI = 56–87 %). Patients who died within 5 years of follow up had significantly higher pre-operative GC-SUVmax (median = 10.6, IQR = 8.3–14.4) than patients who were alive at 5-year follow up (median = 6.4, IQR = 3.0–9.8), p = 0.04. SUVmax showed similar differences: 10.4 (8–12.9) vs. 6.6 (3.0–8.8), p = 0.047. The area under the receiver-operating characteristic (ROC) curve at 5 years was 0.70 (95 % CI = 0.50–0.90) for GC-SUVmax and 0.71 (95 % CI = 0.51–0.91) for SUVmax (p = 0.75).

Conclusion

Pre-operative FDG tumor uptake in patients with NSCLC is predictive for survival after complete surgical resection. GC-SUVmax, as an additional value to SUVmax, may better approach competitive inhibition of FDG and glucose in tumors, however, in this study this potential advantage, if any, was very small.
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Metadata
Title
Prognostic value of pre-operative glucose-corrected maximum standardized uptake value in patients with non-small cell lung cancer after complete surgical resection and 5-year follow-up
Authors
Renske Konings
Matthijs H. van Gool
Martin P. L. Bard
Anthonie Zwijnenburg
Bart M. Titulaer
Tjeerd S. Aukema
Renato A. Valdés Olmos
Karolina Sikorska
Houke M. Klomp
Herman Rijna
Publication date
01-06-2016
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 5/2016
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-016-1070-2

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