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01-06-2014 | Original Article

Is ¹⁸F-FDG PET/CT more reliable than ^99mTc-MDP planar bone scintigraphy in detecting bone metastasis in nasopharyngeal carcinoma?

Authors: Zhongyi Yang, Yongping Zhang, Wei Shi, Beiling Zhu, Silong Hu, Zhifeng Yao, Herong Pan, Chaosu Hu, Yingjian Zhang, Duanshu Li

Published in: Annals of Nuclear Medicine | Issue 5/2014

Abstract

Objective

Bone metastasis occurs frequently in nasopharyngeal carcinoma (NPC) patients. The aim of this study was to compare the clinical value of ¹⁸F-FDG PET/CT with that of ^99mTc-MDP planar bone scintigraphy (PBS) for detecting bone metastasis in NPC patients.

Methods

Thirty-five histologically proven NPC patients were enrolled in this retrospective study. They underwent both ¹⁸F-FDG PET/CT and PBS within 7 days in our department. In a lesion-based analysis, the skeletal system, excluding the head, was divided into four regions: the spine, the pelvis, the thorax, and the appendix. Bone metastasis was considered to be present by either biopsy or clinical follow-up for at least 6 months. PET/CT and PBS were compared by McNemar’s paired-sample test.

Results

A total of 50 lesions were confirmed to be malignant (spine 27, thorax 11, pelvis 8 and appendix 4). Although PET/CT was found to be more sensitive on lesion level than PBS (sensitivity 70.0 versus 42.0 %; P = 0.044), there were still 14 metastatic (28.0 %) lesions that could be detected by PBS while negative in PET/CT imaging. In a patient-based analysis, fifteen (42.9 %) of 35 eligible patients were found to have bone metastasis. The sensitivity, specificity and accuracy of PET/CT was 60.0 % (9/15), 100 % (20/20) and 82.9 % (29/35); as for PBS, it was 66.7 % (10/15), 85.0 % (17/20) and 77.1 % (27/35), respectively. There was no statistical difference between PET/CT and PBS (P > 0.05).

Conclusions

PBS, as a conventional imaging, should be used as an important complement for detecting bone metastasis in NPC patients.

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Title: Is 18F-FDG PET/CT more reliable than 99mTc-MDP planar bone scintigraphy in detecting bone metastasis in nasopharyngeal carcinoma?
Authors: Zhongyi Yang
Yongping Zhang
Wei Shi
Beiling Zhu
Silong Hu
Zhifeng Yao
Herong Pan
Chaosu Hu
Yingjian Zhang
Duanshu Li
Publication date: 01-06-2014
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 5/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-014-0831-z

At a glance: The STEP trials

Springer Medicine

Is ¹⁸F-FDG PET/CT more reliable than ^99mTc-MDP planar bone scintigraphy in detecting bone metastasis in nasopharyngeal carcinoma?

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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