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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 8/2012

Open Access 01-10-2012 | Original article

F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability

Authors: Hidehiro Iida, Ulla Ruotsalainen, Maija Mäki, Merja Haaparnata, Jörgen Bergman, Liisa-Maria Voipio-Pulkki, Pirjo Nuutila, Kazuhiro Koshino, Juhani Knuuti

Published in: Annals of Nuclear Medicine | Issue 8/2012

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Abstract

Objectives

15O-water-perfusable tissue fraction (PTF) has been shown to be a potential index for assessing myocardial viability in PET, an alternative to 18F-fluorodeoxyglucose (FDG). This study aimed to directly compare these two independent methods in assessing myocardial viability in patients with abnormal wall motion.

Methods

PET study was performed on 16 patients with previous myocardial infarction, before coronary artery bypass graft operation (CABG). The protocol included a 15O-carbonmonoxide static, a 15O-water dynamic and an 18F-FDG dynamic scan, during the euglycemic hyperinsulinemic clamp. Echocardiography was performed at the time of PET and 5–12 months after the CABG, and the wall motion recovery was evaluated on segmental and global bases. Consistency between PTF and 18F-FDG was evaluated visually and also in a quantitative manner. Predictive values for the wall motion recovery were also compared between the two approaches.

Results

The image quality of 18F-FDG was superior to that of 15O-water. The qualitative PTF showed significantly smaller defects than 18F-FDG, and the quantitative PTF showed slightly greater values than 18F-FDG in the infarcted region. The two methods were, however, consistent visually and also quantitatively. The predictive values of the wall motion recovery were almost equal between the two approaches. The absolute 18F-FDG uptake was varied in normal segments, and predictive values for the wall motion recovery by the absolute 18F-FDG was less (accuracy: 80 %) compared with those by the relative 18F-FDG (accuracy: 87 %) and the quantitative PTF (accuracy: 89 %).

Conclusion

Despite the small sample size, PTF appears to give consistent results with the 18F-FDG approach, and might be an alternative viability assessment.
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Metadata
Title
F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability
Authors
Hidehiro Iida
Ulla Ruotsalainen
Maija Mäki
Merja Haaparnata
Jörgen Bergman
Liisa-Maria Voipio-Pulkki
Pirjo Nuutila
Kazuhiro Koshino
Juhani Knuuti
Publication date
01-10-2012
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 8/2012
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-012-0631-2

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