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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 9/2011

01-11-2011 | Original article

Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey

Authors: Takeshi Murano, Ryogo Minamimoto, Michio Senda, Kimiichi Uno, Seishi Jinnouchi, Hiroshi Fukuda, Takeshi Iinuma, Eriko Tsukamoto, Takashi Terauchi, Tsuyoshi Yoshida, Shinya Oku, Sadahiko Nishizawa, Kengo Ito, Kazuhiro Oguchi, Masami Kawamoto, Rumi Nakashima, Hiroshi Iwata, Tomio Inoue

Published in: Annals of Nuclear Medicine | Issue 9/2011

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Abstract

Objective

The aim of this study was to estimate radiation exposure and evaluate the risks and benefits of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in cancer screening.

Methods

A nationwide survey of FDG-PET cancer screening was conducted in 2006, and the results were analyzed with a common index, “extension/shortening of the average life expectancy.”

Results

The average estimated effective dose was 4.4 mSv (male 4.7 mSv; female 4.0 mSv) for dedicated PET and 13.5 mSv (male 14.2 mSv; female 12.8 mSv) for PET/computed tomography (CT). The risk–benefit break-even age from the viewpoint of radiation exposure was in the 40s for men and 30s for women for dedicated PET and in the 50s for men and 50s (variable injection dose) or 60s (constant injection dose) for women for PET/CT.

Conclusions

FDG-PET cancer screening is beneficial for examinees above the break-even ages. The risks and benefits should be explained to examinees because of the larger radiation used in cancer FDG-PET screening compared with other X-ray tests.
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Metadata
Title
Radiation exposure and risk–benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey
Authors
Takeshi Murano
Ryogo Minamimoto
Michio Senda
Kimiichi Uno
Seishi Jinnouchi
Hiroshi Fukuda
Takeshi Iinuma
Eriko Tsukamoto
Takashi Terauchi
Tsuyoshi Yoshida
Shinya Oku
Sadahiko Nishizawa
Kengo Ito
Kazuhiro Oguchi
Masami Kawamoto
Rumi Nakashima
Hiroshi Iwata
Tomio Inoue
Publication date
01-11-2011
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 9/2011
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-011-0511-1

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