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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 5/2010

01-06-2010 | Original Article

FDG-PET/CT imaging in assessing mucin-producing non-small cell lung cancer with pathologic correlation

Authors: Sung Shine Shim, Joungho Han

Published in: Annals of Nuclear Medicine | Issue 5/2010

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Abstract

Objective

The objective of this study was to describe the PET/CT findings of mucin-producing non-small cell lung cancer (NSCLC) and how those findings are associated with pathology.

Methods

A review of all patients with FDG-PET/CT identified 11 patients with histopathologically confirmed mucin-producing NSCLC; 3 mucinous bronchioloalveolar carcinoma (mBAC), 5 mixed-type adenocarcinoma with prominent mucinous BAC pattern (ADENO + mBAC), and 3 mixed-type adenocarcinoma with mucin production (ADENO + MUCIN) in our institute.

Results

Among 11 patients, only 2 lesions (18%) evidenced positive PET results for standardized uptake value (SUV) of 3.5 (by ROC analysis) whereas all cases were detected correctly at CT. The mean SUV was 2.0 in the 9 lesions not detected and 2.5 in all cases. The mean SUV of pure mBAC was 1.93, that of mucin-producing adenocarcinoma was 2.69 without a significant difference (p = 0.279). No significant correlations between tumor size or stage and SUV were determined.

Conclusions

PET/CT for SUV is limited in the detection of mucin-producing NSCLC. Therefore, the CT component of PET/CT may allow for significantly improved sensitivity and help to reduce delayed diagnose. The SUV in mBACs were lower than the other types of mucin-producing adenocarcinoma; however, we determined no significant difference to exist between the SUVs of two groups of lung cancer.
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Metadata
Title
FDG-PET/CT imaging in assessing mucin-producing non-small cell lung cancer with pathologic correlation
Authors
Sung Shine Shim
Joungho Han
Publication date
01-06-2010
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 5/2010
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-010-0358-x

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