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Published in: Annals of Nuclear Medicine 4/2009

01-06-2009 | Case Report

Findings of hepatopulmonary syndrome on breath-hold perfusion SPECT-CT fusion images

Authors: Kazuyoshi Suga, Yasuhiko Kawakami, Hideyuki Iwanaga, Osamu Tokuda, Naofumi Matsunaga

Published in: Annals of Nuclear Medicine | Issue 4/2009

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Abstract

Pulmonary perfusion SPECT-CT fusion images were used to characterize CT manifestations of intrapulmonary arteriovenous communications (AVC) causing right-to-left shunt and hepatopulmonary syndrome (HPS). After scanning the whole body and obtaining multiple view images of the lung, deep-inspiratory breath-hold (DIBrH) SPECT was obtained in 2 patients with HPS, which was automatically and three-dimensionally co-registered with DIBrH CT. In both patients, the whole body scan depicted systemic organs and confirmed the existence of right-to-left shunt. DIBrH SPECT-CT fusion images showed that perfusion defects were predominantly located at subpleural reticulo-nodular opacities and/or dilated vessels in the lung base. Subpleural reticulo-nodular opacities and/or dilated vessels in the lung base appear to be characteristic CT manifestation of intrapulmonary AVC in HPS.
Literature
1.
go back to reference Colle I, Van Steenkiste C, Geerts A, Van Vlierberghe H. Hepatopulmonary syndrome and portopulmonary hypertension: what’s new? Acta Gastroenterol Belg. 2007;70:203–9.PubMed Colle I, Van Steenkiste C, Geerts A, Van Vlierberghe H. Hepatopulmonary syndrome and portopulmonary hypertension: what’s new? Acta Gastroenterol Belg. 2007;70:203–9.PubMed
2.
go back to reference Herve P, Le Pavec J, Sztrymf B, Decante B, Savale L, Sitbon O. Pulmonary vascular abnormalities in cirrhosis. Best Pract Res Clin Gastroenterol. 2007;21:141–59.PubMedCrossRef Herve P, Le Pavec J, Sztrymf B, Decante B, Savale L, Sitbon O. Pulmonary vascular abnormalities in cirrhosis. Best Pract Res Clin Gastroenterol. 2007;21:141–59.PubMedCrossRef
3.
go back to reference Hoeper MM, Krowka MJ, Strassburg CP. Portopulmonary hypertension and hepatopulmonary syndrome. Lancet. 2004;363:1461–8.PubMedCrossRef Hoeper MM, Krowka MJ, Strassburg CP. Portopulmonary hypertension and hepatopulmonary syndrome. Lancet. 2004;363:1461–8.PubMedCrossRef
4.
go back to reference Rodríguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome—a liver-induced lung vascular disorder. N Engl J Med. 2008;358:2378–87.PubMedCrossRef Rodríguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome—a liver-induced lung vascular disorder. N Engl J Med. 2008;358:2378–87.PubMedCrossRef
5.
go back to reference Ferraz-Neto BH, Zurstrassen MP, Hidalgo R, Meira-Filho SP, Rezende MB, Paes AT, et al. Analysis of liver transplantation outcome in patients with MELD Score > or = 30. Transplant Proc. 2008;40:797–9.PubMedCrossRef Ferraz-Neto BH, Zurstrassen MP, Hidalgo R, Meira-Filho SP, Rezende MB, Paes AT, et al. Analysis of liver transplantation outcome in patients with MELD Score > or = 30. Transplant Proc. 2008;40:797–9.PubMedCrossRef
6.
go back to reference Hosono M, Machida K, Honda N, Takahashi T, Kashimada A, Osada H, et al. Quantitative lung perfusion scintigraphy and detection of intrapulmonary shunt in liver cirrhosis. Ann Nucl Med. 2002;16:577–81.PubMedCrossRef Hosono M, Machida K, Honda N, Takahashi T, Kashimada A, Osada H, et al. Quantitative lung perfusion scintigraphy and detection of intrapulmonary shunt in liver cirrhosis. Ann Nucl Med. 2002;16:577–81.PubMedCrossRef
7.
go back to reference Köksal D, Kaçar S, Köksal AS, Tüfekçioğlu O, Küçükay F, Okten S, et al. Evaluation of intrapulmonary vascular dilatations with high-resolution computed thorax tomography in patients with hepatopulmonary syndrome. J Clin Gastroenterol. 2006;40:77–83.PubMedCrossRef Köksal D, Kaçar S, Köksal AS, Tüfekçioğlu O, Küçükay F, Okten S, et al. Evaluation of intrapulmonary vascular dilatations with high-resolution computed thorax tomography in patients with hepatopulmonary syndrome. J Clin Gastroenterol. 2006;40:77–83.PubMedCrossRef
8.
go back to reference Shafiq M, Khan AA, Alam A, Butt AK, Shafqat F, Malik K, et al. Frequency of hepatopulmonary syndrome in cirrhotic patients. J Coll Physicians Surg Pak. 2008;18:278–81.PubMed Shafiq M, Khan AA, Alam A, Butt AK, Shafqat F, Malik K, et al. Frequency of hepatopulmonary syndrome in cirrhotic patients. J Coll Physicians Surg Pak. 2008;18:278–81.PubMed
9.
go back to reference McAdams HP, Erasmus J, Crockett R, Mitchell J, Godwin JD, McDermott VG. The hepatopulmonary syndrome: radiologic findings in 10 patients. Am J Roentgenol. 1996;166:1379–85. McAdams HP, Erasmus J, Crockett R, Mitchell J, Godwin JD, McDermott VG. The hepatopulmonary syndrome: radiologic findings in 10 patients. Am J Roentgenol. 1996;166:1379–85.
10.
go back to reference Ketai L, Hartshorne M. Potential of computed tomography-SPECT and computed tomography—coincidence fusion images of the chest. Clin Nucl Med. 2001;26:433–41.PubMedCrossRef Ketai L, Hartshorne M. Potential of computed tomography-SPECT and computed tomography—coincidence fusion images of the chest. Clin Nucl Med. 2001;26:433–41.PubMedCrossRef
11.
go back to reference Damen EM, Muller SH, Boersma LJ, de Boer RW, Lebesque JV. Quantifying local lung perfusion and ventilation using correlated SPECT and CT data. J Nucl Med. 1994;35:784–92.PubMed Damen EM, Muller SH, Boersma LJ, de Boer RW, Lebesque JV. Quantifying local lung perfusion and ventilation using correlated SPECT and CT data. J Nucl Med. 1994;35:784–92.PubMed
12.
go back to reference Zaki M, Suga K, Kawakami Y, Yamashita T, Shimizu K, Seto A, et al. Preferential location of acute pulmonary thromboembolism-induced consolidative opacities; assessment with respiratory-gated perfusion SPECT-CT fusion images. Nucl Med Commun. 2005;26:465–74.PubMedCrossRef Zaki M, Suga K, Kawakami Y, Yamashita T, Shimizu K, Seto A, et al. Preferential location of acute pulmonary thromboembolism-induced consolidative opacities; assessment with respiratory-gated perfusion SPECT-CT fusion images. Nucl Med Commun. 2005;26:465–74.PubMedCrossRef
13.
go back to reference Suga K, Kawakami Y, Zaki M, Tanaka N, Matsumoto T, Matsunaga N. Assessment of regional lung functional impairment with co-registered respiratory-gated ventilation/perfusion SPET-CT images: initial experiences. Eur J Nucl Med Mol Imaging. 2004;31:240–9.PubMedCrossRef Suga K, Kawakami Y, Zaki M, Tanaka N, Matsumoto T, Matsunaga N. Assessment of regional lung functional impairment with co-registered respiratory-gated ventilation/perfusion SPET-CT images: initial experiences. Eur J Nucl Med Mol Imaging. 2004;31:240–9.PubMedCrossRef
14.
go back to reference Suga K, Kawakami Y, Iwanaga H, Hayashi N, Seto A, Matsunaga N. Comprehensive assessment of lung CT attenuation alteration at perfusion defects of acute pulmonary thromboembolism with breath-hold SPECT-CT fusion images. J Comput Assist Tomogr. 2006;30:83–91.PubMedCrossRef Suga K, Kawakami Y, Iwanaga H, Hayashi N, Seto A, Matsunaga N. Comprehensive assessment of lung CT attenuation alteration at perfusion defects of acute pulmonary thromboembolism with breath-hold SPECT-CT fusion images. J Comput Assist Tomogr. 2006;30:83–91.PubMedCrossRef
15.
go back to reference Suga K, Kawakami Y, Iwanaga H, Tokuda O, Matsunaga N. Automated breath-Hold perfusion SPECT-CT fusion images. Am J Roentgenol. 2007;189:455–63.CrossRef Suga K, Kawakami Y, Iwanaga H, Tokuda O, Matsunaga N. Automated breath-Hold perfusion SPECT-CT fusion images. Am J Roentgenol. 2007;189:455–63.CrossRef
16.
go back to reference Sudoh M, Ueda K, Kaneda Y, Mitsutaka J, Li TS, Suga K, et al. Breath-hold single-photon emission tomography and computed tomography for predicting residual pulmonary function in patients with lung cancer. J Thoracic Cardiovasc Surg. 2006;131:994–1001.CrossRef Sudoh M, Ueda K, Kaneda Y, Mitsutaka J, Li TS, Suga K, et al. Breath-hold single-photon emission tomography and computed tomography for predicting residual pulmonary function in patients with lung cancer. J Thoracic Cardiovasc Surg. 2006;131:994–1001.CrossRef
17.
go back to reference Ardekani BA, Braun M, Hutton BF, Kanno I, Iida H. A fully automatic multimodality image registration algorithm. J Comput Assist Tomogr. 1995;19:615–23.PubMedCrossRef Ardekani BA, Braun M, Hutton BF, Kanno I, Iida H. A fully automatic multimodality image registration algorithm. J Comput Assist Tomogr. 1995;19:615–23.PubMedCrossRef
18.
go back to reference Sty JR, Thomas N, Gallen W. Congenital pulmonary arteriovenous aneurysm. Clin Nucl Med. 1981;6:86–8.PubMedCrossRef Sty JR, Thomas N, Gallen W. Congenital pulmonary arteriovenous aneurysm. Clin Nucl Med. 1981;6:86–8.PubMedCrossRef
19.
go back to reference Yol S, Erikoglu M, Toprak SS, Tavlı S, Tavlı L. The effects of serum estrogen levels on hypoxemia and blood nitric oxide levels in experimental hepatopulmonary syndrome. Hepatol Res. 2005;33:7–13.PubMedCrossRef Yol S, Erikoglu M, Toprak SS, Tavlı S, Tavlı L. The effects of serum estrogen levels on hypoxemia and blood nitric oxide levels in experimental hepatopulmonary syndrome. Hepatol Res. 2005;33:7–13.PubMedCrossRef
20.
go back to reference Alderson PO, Vieras F, Housholder DF, Medenhall KG, Warner HN Jr. Gated and cinematic perfusion lung imaging in dogs with experimental pulmonary embolism. J Nucl Med. 1979;20:407–12.PubMed Alderson PO, Vieras F, Housholder DF, Medenhall KG, Warner HN Jr. Gated and cinematic perfusion lung imaging in dogs with experimental pulmonary embolism. J Nucl Med. 1979;20:407–12.PubMed
21.
go back to reference Yu JN, Fahey FH, Gage HD, Eades CG, Harkness BA, Pelizzari CA, et al. Intermodality, retrospective image registration in the thorax. J Nucl Med. 1995;36:2333–8.PubMed Yu JN, Fahey FH, Gage HD, Eades CG, Harkness BA, Pelizzari CA, et al. Intermodality, retrospective image registration in the thorax. J Nucl Med. 1995;36:2333–8.PubMed
22.
go back to reference Gutman F, Hangard G, Gardin I, Varmenot N, Pattyn J, Clement JF, et al. Evaluation of a rigid registration method of lung perfusion SPECT and thoracic CT. Am J Roentgenol. 2005;185:1516–24.CrossRef Gutman F, Hangard G, Gardin I, Varmenot N, Pattyn J, Clement JF, et al. Evaluation of a rigid registration method of lung perfusion SPECT and thoracic CT. Am J Roentgenol. 2005;185:1516–24.CrossRef
23.
go back to reference Nagasawa K, Takahashi K, Furuse M, Yamada T, Mineta M, Yamamoto W, et al. Imaging findings of pulmonary vascular disorders in portal hypertension. Nippon Igaku Hoshasen Gakkai Zasshi. 2004;64:294–9.PubMed Nagasawa K, Takahashi K, Furuse M, Yamada T, Mineta M, Yamamoto W, et al. Imaging findings of pulmonary vascular disorders in portal hypertension. Nippon Igaku Hoshasen Gakkai Zasshi. 2004;64:294–9.PubMed
24.
go back to reference Noma S, Moskowitz GW, Herman PG. Pulmonary scintigraphy in elastase-induced emphysema in pigs. Correlation with high-resolution computed tomography and histology. Invest Radiol. 1992;27:429–35.PubMedCrossRef Noma S, Moskowitz GW, Herman PG. Pulmonary scintigraphy in elastase-induced emphysema in pigs. Correlation with high-resolution computed tomography and histology. Invest Radiol. 1992;27:429–35.PubMedCrossRef
25.
go back to reference Suga K, Kuramitsu T, Yoshimizu T, Nakanishi T, Yamada N, Utsumi N. Scintigraphic analysis of hemodynamics in a patient with a single large pulmonary arteriovenous fistula. Clin Nucl Med. 1992;17:110–3.PubMedCrossRef Suga K, Kuramitsu T, Yoshimizu T, Nakanishi T, Yamada N, Utsumi N. Scintigraphic analysis of hemodynamics in a patient with a single large pulmonary arteriovenous fistula. Clin Nucl Med. 1992;17:110–3.PubMedCrossRef
26.
go back to reference Andersen PE, Kjeldsen AD, Oxhøj H, Vase P, White RI Jr. Embolotherapy for pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia (Rendu–Osler–Weber syndrome). Acta Radiol. 1998;39:723–6.PubMedCrossRef Andersen PE, Kjeldsen AD, Oxhøj H, Vase P, White RI Jr. Embolotherapy for pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia (Rendu–Osler–Weber syndrome). Acta Radiol. 1998;39:723–6.PubMedCrossRef
27.
go back to reference White RI Jr, Pollak JS. Pulmonary arteriovenous malformations: diagnosis with three-dimensional helical CT; a breakthrough without contrast media (editorial; comment). Radiology. 1994;191:613–4.PubMed White RI Jr, Pollak JS. Pulmonary arteriovenous malformations: diagnosis with three-dimensional helical CT; a breakthrough without contrast media (editorial; comment). Radiology. 1994;191:613–4.PubMed
28.
go back to reference Engeler CE, Kuni CC, Tashjian JH, Engeler CM, du Cret RP. Regional alterations in lung ventilation in end-stage primary pulmonary hypertension: correlation between CT and scintigraphy. Am J Roentgenol. 1995;164:831–5. Engeler CE, Kuni CC, Tashjian JH, Engeler CM, du Cret RP. Regional alterations in lung ventilation in end-stage primary pulmonary hypertension: correlation between CT and scintigraphy. Am J Roentgenol. 1995;164:831–5.
29.
go back to reference Ogawa Y, Ashizawa K, Hashmi R, Takemoto Y, Hayashi K. Regional ventilation-perfusion mismatch in interstitial pneumonia. Correlation between scintigraphy and CT. Clin Nucl Med. 1997;22:166–71.PubMedCrossRef Ogawa Y, Ashizawa K, Hashmi R, Takemoto Y, Hayashi K. Regional ventilation-perfusion mismatch in interstitial pneumonia. Correlation between scintigraphy and CT. Clin Nucl Med. 1997;22:166–71.PubMedCrossRef
30.
go back to reference Slater JP, Goldstein DJ, Ashton RC Jr, Levin HR, Spotnitz HM, Oz MC. Right-to-left veno-arterial shunting for right-sided circulatory failure. Ann Thorac Surg. 1995;60:978–84.PubMedCrossRef Slater JP, Goldstein DJ, Ashton RC Jr, Levin HR, Spotnitz HM, Oz MC. Right-to-left veno-arterial shunting for right-sided circulatory failure. Ann Thorac Surg. 1995;60:978–84.PubMedCrossRef
31.
go back to reference Krowka MJ, Tajik AJ, Dickson ER, Wiesner RH, Cortese DA. Intrapulmonary vascular dilatations in liver transplant candidates; screening by two-dimensional contrast enhanced echocardiography. Chest. 1990;97:1165–70.PubMedCrossRef Krowka MJ, Tajik AJ, Dickson ER, Wiesner RH, Cortese DA. Intrapulmonary vascular dilatations in liver transplant candidates; screening by two-dimensional contrast enhanced echocardiography. Chest. 1990;97:1165–70.PubMedCrossRef
32.
go back to reference Abrams GA, Jaffe CC, Hoffer PB, Binder HJ, Fallon MB. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology. 1995;109:1283–8.PubMedCrossRef Abrams GA, Jaffe CC, Hoffer PB, Binder HJ, Fallon MB. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology. 1995;109:1283–8.PubMedCrossRef
Metadata
Title
Findings of hepatopulmonary syndrome on breath-hold perfusion SPECT-CT fusion images
Authors
Kazuyoshi Suga
Yasuhiko Kawakami
Hideyuki Iwanaga
Osamu Tokuda
Naofumi Matsunaga
Publication date
01-06-2009
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 4/2009
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-009-0250-8

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