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01-03-2021 | Langerhans Cell Histiocytosis | Case Reports

Rosai–Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature

Authors: Aileen Azari-Yaam, Mohammad Reza Abdolsalehi, Mohammad Vasei, Moeinadin Safavi, Mehrzad Mehdizadeh

Published in: Head and Neck Pathology | Issue 1/2021

Abstract

Rosai–Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients.

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Title: Rosai–Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature
Authors: Aileen Azari-Yaam
Mohammad Reza Abdolsalehi
Mohammad Vasei
Moeinadin Safavi
Mehrzad Mehdizadeh
Publication date: 01-03-2021
Publisher: Springer US
Keywords: Langerhans Cell Histiocytosis
Histiocytosis
Epistaxis
Lymphadenopathy
Published in: Head and Neck Pathology / Issue 1/2021
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-020-01183-7

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Rosai–Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature

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