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01-03-2021 | Case Reports

Central Odontogenic Fibroma with Giant Cell Granuloma-Like Lesion: A Report of an Additional Case and Review of Literature

Authors: Omneya R. Ramadan, Marwa M. Essawy

Published in: Head and Neck Pathology | Issue 1/2021

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Abstract

Central odontogenic fibroma is a rare benign odontogenic tumor that relies on clinical–radiographic–histological correlation to reach its diagnosis, especially its rare variants. Of these rare types is the coexistence of giant cell granuloma-like lesion, with the characteristic odontogenic epithelial rests. The presented case is a 33 years old female complaining of asymptomatic mandibular bony swelling. Radiographically, the lesion is unilocular radiolucent, without root resorption. Histological examination revealed the presence of multinucleated giant cells within the diagnosed central odontogenic fibroma. Immunohistochemical staining highlighted the presence of both components.
Literature
1.
go back to reference Barnes L, Eveson J, Reichart P, editors. World health organization classifications tumours. Pathology and genetics of head and neck tumours. Lyon: Iarc; 2005. p 315. Barnes L, Eveson J, Reichart P, editors. World health organization classifications tumours. Pathology and genetics of head and neck tumours. Lyon: Iarc; 2005. p 315.
2.
go back to reference Regezi JA, Sciubba J, Jordan RC. Oral pathology: clinical pathologic correlations. Missouri: Saunders; 2003. pp 280–1. Regezi JA, Sciubba J, Jordan RC. Oral pathology: clinical pathologic correlations. Missouri: Saunders; 2003. pp 280–1.
3.
go back to reference Neville BW, Damm DD, Allen CM, editors. Oral and maxillofacial pathology. Philadelphia: Saunders; 2002. p. 633–4. Neville BW, Damm DD, Allen CM, editors. Oral and maxillofacial pathology. Philadelphia: Saunders; 2002. p. 633–4.
4.
go back to reference Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68–77.CrossRef Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68–77.CrossRef
5.
go back to reference Vincent SD, Hammond HL, Ellis GL et al. Central granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol. 1987;63(6):715–21.CrossRef Vincent SD, Hammond HL, Ellis GL et al. Central granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol. 1987;63(6):715–21.CrossRef
6.
go back to reference Gunhan O, Gurbuzer B, Gardner DG et al. A central odontogenic fibroma exhibiting pleomorphic fibroblasts and numerous calcifications. Br J Oral Maxillofac Surg. 1991;29(1):42–3.CrossRef Gunhan O, Gurbuzer B, Gardner DG et al. A central odontogenic fibroma exhibiting pleomorphic fibroblasts and numerous calcifications. Br J Oral Maxillofac Surg. 1991;29(1):42–3.CrossRef
7.
go back to reference Allen CM, Hammond HL, Stimson PG. Central odontogenic fibroma, who type. A report of three cases with an unusual associated giant cell reaction. Oral Surg Oral Med Oral Pathol. 1992;73(1):62–6.CrossRef Allen CM, Hammond HL, Stimson PG. Central odontogenic fibroma, who type. A report of three cases with an unusual associated giant cell reaction. Oral Surg Oral Med Oral Pathol. 1992;73(1):62–6.CrossRef
8.
go back to reference Odell EW, Lombardi T, Barrett AW et al. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesions of the jaws. Histopathology. 1997;30(2):165–71.CrossRef Odell EW, Lombardi T, Barrett AW et al. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesions of the jaws. Histopathology. 1997;30(2):165–71.CrossRef
9.
go back to reference Mosqueda-Taylor A, Bermudez-Flores V, Diaz-Franco MA. Combined central odontogenic fibroma and giant cell granuloma-like lesion of the mandible: Report of a case and review of the literature. J Oral Maxillofac Surg. 1999;57(10):1258–62.CrossRef Mosqueda-Taylor A, Bermudez-Flores V, Diaz-Franco MA. Combined central odontogenic fibroma and giant cell granuloma-like lesion of the mandible: Report of a case and review of the literature. J Oral Maxillofac Surg. 1999;57(10):1258–62.CrossRef
10.
go back to reference Wangerin K, Harms D. Seltene variationen des ameloblastischen fibroms. Dtsch Z Mund Kifer GesichtsChir. 1985;9:227–31. Wangerin K, Harms D. Seltene variationen des ameloblastischen fibroms. Dtsch Z Mund Kifer GesichtsChir. 1985;9:227–31.
11.
go back to reference Younis RH, Scheper MA, Lindquist CC et al. Hybrid central odontogenic fibroma with giant cell granuloma-like component: case report and review of literature. Head Neck Pathol. 2008;2(3):222–6.CrossRef Younis RH, Scheper MA, Lindquist CC et al. Hybrid central odontogenic fibroma with giant cell granuloma-like component: case report and review of literature. Head Neck Pathol. 2008;2(3):222–6.CrossRef
12.
go back to reference Tosios KI, Gopalakrishnan R, Koutlas IG. So-called hybrid central odontogenic fibroma/central giant cell lesion of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Head Neck Pathol. 2008;2(4):333–8.CrossRef Tosios KI, Gopalakrishnan R, Koutlas IG. So-called hybrid central odontogenic fibroma/central giant cell lesion of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Head Neck Pathol. 2008;2(4):333–8.CrossRef
13.
go back to reference de Lima Mde D, de Aquino Xavier FC, Vanti LA et al. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesion of the mandible. Otolaryngol Head Neck Surg. 2008;139(6):867–8.CrossRef de Lima Mde D, de Aquino Xavier FC, Vanti LA et al. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesion of the mandible. Otolaryngol Head Neck Surg. 2008;139(6):867–8.CrossRef
14.
go back to reference Mosqueda-Taylor A, Martinez-Mata G, Carlos-Bregni R et al. Central odontogenic fibroma: new findings and report of a multicentric collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):349–58.CrossRef Mosqueda-Taylor A, Martinez-Mata G, Carlos-Bregni R et al. Central odontogenic fibroma: new findings and report of a multicentric collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):349–58.CrossRef
15.
go back to reference Eversole LR. Odontogenic fibroma, including amyloid and ossifying variants. Head Neck Pathol. 2011;5(4):335–43.CrossRef Eversole LR. Odontogenic fibroma, including amyloid and ossifying variants. Head Neck Pathol. 2011;5(4):335–43.CrossRef
16.
go back to reference Bologna Molina R, Pacheco Ruiz L, Mosqueda Taylor A et al. Central odontogenic fibroma combined with central giant cell lesion of the mandible. Immunohistochemical profile. J Clin Exp Dent. 2011;3(4):e348-51. Bologna Molina R, Pacheco Ruiz L, Mosqueda Taylor A et al. Central odontogenic fibroma combined with central giant cell lesion of the mandible. Immunohistochemical profile. J Clin Exp Dent. 2011;3(4):e348-51.
17.
go back to reference Damm DD. Interradicular radiolucency. Hybrid giant cell granuloma and odontogenic fibroma. Gen Dent. 2013;61(3):77–8.PubMed Damm DD. Interradicular radiolucency. Hybrid giant cell granuloma and odontogenic fibroma. Gen Dent. 2013;61(3):77–8.PubMed
18.
go back to reference Eliot C, Kessler HP. Clinical pathologic conference case 1: a multilocular radiolucency in the posterior mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(6):289–92.CrossRef Eliot C, Kessler HP. Clinical pathologic conference case 1: a multilocular radiolucency in the posterior mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(6):289–92.CrossRef
19.
go back to reference Upadhyaya JD, Cohen DM, Islam MN et al. Hybrid central odontogenic fibroma with giant cell granuloma like lesion: a report of three additional cases and review of the literature. Head Neck Pathol. 2018;12(2):166–74.CrossRef Upadhyaya JD, Cohen DM, Islam MN et al. Hybrid central odontogenic fibroma with giant cell granuloma like lesion: a report of three additional cases and review of the literature. Head Neck Pathol. 2018;12(2):166–74.CrossRef
20.
go back to reference Flores-Hidalgo A, Biggerstaff T, Murrah V. Hybrid central odontogenic fibroma and central giant cell granuloma lesion–a case report of an aggressive and recurrent lesion. J Oral Maxillofac Surg Med Pathol. 2019;31(6):432–4.CrossRef Flores-Hidalgo A, Biggerstaff T, Murrah V. Hybrid central odontogenic fibroma and central giant cell granuloma lesion–a case report of an aggressive and recurrent lesion. J Oral Maxillofac Surg Med Pathol. 2019;31(6):432–4.CrossRef
21.
go back to reference Fowler C, Tomich C, Brannon R et al. Central odontogenic fibroma: clinicopathologic features of 24 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1993;76:587.CrossRef Fowler C, Tomich C, Brannon R et al. Central odontogenic fibroma: clinicopathologic features of 24 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1993;76:587.CrossRef
22.
go back to reference Kessler H. Western society of teachers of oral pathology. Wyoming: Jackson Hole; 2006. Kessler H. Western society of teachers of oral pathology. Wyoming: Jackson Hole; 2006.
23.
go back to reference Hassan S, Reich R, Freedman P. Central odontogenic fibroma with associated central giant cell granuloma (collision tumor?): report of 7 cases. 62nd Annual Meeting, American Academy of Oral and Maxillofacial Pathology. San Francisca. 2008. Hassan S, Reich R, Freedman P. Central odontogenic fibroma with associated central giant cell granuloma (collision tumor?): report of 7 cases. 62nd Annual Meeting, American Academy of Oral and Maxillofacial Pathology. San Francisca. 2008.
24.
go back to reference Schultz K, Rosebush M. Clinical pathologic conference case 3. Annual Meeting of the American Academy of Oral and Maxillofacial Pathology. Newport, Rhode Island. 2017. Schultz K, Rosebush M. Clinical pathologic conference case 3. Annual Meeting of the American Academy of Oral and Maxillofacial Pathology. Newport, Rhode Island. 2017.
25.
go back to reference Leite T, Mendes E, Abrahao A et al. Central odontogenic fibroma: Report of three new cases from brazil. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(3):e229–30.CrossRef Leite T, Mendes E, Abrahao A et al. Central odontogenic fibroma: Report of three new cases from brazil. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(3):e229–30.CrossRef
26.
go back to reference Wesley RK, Wysocki GP, Mintz SM. The central odontogenic fibroma. Clinical and morphologic studies. Oral Surg Oral Med Oral Pathol. 1975;40(2):235–45.CrossRef Wesley RK, Wysocki GP, Mintz SM. The central odontogenic fibroma. Clinical and morphologic studies. Oral Surg Oral Med Oral Pathol. 1975;40(2):235–45.CrossRef
27.
go back to reference Gardner DG. The central odontogenic fibroma: an attempt at clarification. Oral Surg Oral Med Oral Pathol. 1980;50(5):425–32.CrossRef Gardner DG. The central odontogenic fibroma: an attempt at clarification. Oral Surg Oral Med Oral Pathol. 1980;50(5):425–32.CrossRef
28.
go back to reference Gardner DG. Central odontogenic fibroma current concepts. J Oral Pathol Med. 1996;25(10):556–61.CrossRef Gardner DG. Central odontogenic fibroma current concepts. J Oral Pathol Med. 1996;25(10):556–61.CrossRef
29.
go back to reference Kawakami T, Antoh M, Minemura T. Giant cell reaction to ameloblastoma: an immunohistochemical and ultrastructural study of a case. J Oral Maxillofac Surg. 1989;47(7):737–41.CrossRef Kawakami T, Antoh M, Minemura T. Giant cell reaction to ameloblastoma: an immunohistochemical and ultrastructural study of a case. J Oral Maxillofac Surg. 1989;47(7):737–41.CrossRef
30.
go back to reference Ikeshima A, Utsunomiya T. Case report of intra-osseous fibroma: a study on odontogenic and desmoplastic fibromas with a review of the literature. J Oral Sci. 2005;47(3):149–57.CrossRef Ikeshima A, Utsunomiya T. Case report of intra-osseous fibroma: a study on odontogenic and desmoplastic fibromas with a review of the literature. J Oral Sci. 2005;47(3):149–57.CrossRef
31.
go back to reference Regezi JA. Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws. Mod Pathol. 2002;15(3):331–41.CrossRef Regezi JA. Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws. Mod Pathol. 2002;15(3):331–41.CrossRef
Metadata
Title
Central Odontogenic Fibroma with Giant Cell Granuloma-Like Lesion: A Report of an Additional Case and Review of Literature
Authors
Omneya R. Ramadan
Marwa M. Essawy
Publication date
01-03-2021
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2021
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-020-01153-z