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Published in: Head and Neck Pathology 3/2017

01-09-2017 | Review Paper

Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective

Authors: Marwah Abbas Hassan Aldalwg, Brian Brestovac

Published in: Head and Neck Pathology | Issue 3/2017

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Abstract

Human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCCs), have become a serious global health problem. Despite decreases in HPV-negative HNSCCs, the prevalence of HPV-positive HNSCCs has significantly increased. HPV-positive cancers are associated with superior survival outcomes when compared to HPV-negative cancers, which appears likely to be associated with differences in the molecular pathogenesis of the two diseases. While therapies are still problematic, the current HPV vaccine programs hold a promise for the primary prevention of HPV-related HNSCCs and since Australia was the first to introduce a nationwide HPV vaccine program, it is in a unique position to observe the effects of the vaccine on HNSCCs. This review discusses the epidemiological trends associated with HPV in HNSCC, with reference to the differences between HPV-positive and HPV-negative HNSCCs and the prevention potential of HPV vaccines.
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Metadata
Title
Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective
Authors
Marwah Abbas Hassan Aldalwg
Brian Brestovac
Publication date
01-09-2017
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2017
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-017-0780-7

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